Synthesis of new spiroheterocycles-fused isoxazoline from 2-arylidenes-3-phenyl-1-indanones through a regio-and diastereospecific 1,3-dipolar cycloaddition

Abstract

<p>New spiroisoxazolines <strong>3</strong> have been synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and diastereospecific manner and leads to one cycloadduct in all the cases. The proposed structure of the obtained cycloadducts was established based on spectroscopic data and confirmed by radiocrystallographic study. The spectral data were in favor of the observed regiochemistry and diastereoselectivity of this reaction.</p>

Lung Cancer Properties of Veronica officinalis L.

“…The Maestro Molecular modeling platform (version 12.8) by Schrödinger [16,17] was utilized for these calculations. Various modules, including protein preparation [18,19], LigPrep [20,21], and Glide ligand docking [22,23], were applied in the molecular docking calculations. The OPLS4 method was employed for all calculations, providing a comprehensive approach to explore potential interactions between the investigated molecules and antioxidant proteins [24].…”

Colon Cancer Properties of Sideritis Libanotica

“…The Maestro Molecular modeling platform (version 12.8) by Schrödinger [19,20] was utilized for these calculations. Various modules, including protein preparation [21,22], LigPrep [23,24], and Glide ligand docking [25,26], were applied in the molecular docking calculations. The OPLS4 method was employed for all calculations, providing a comprehensive approach to explore potential interactions between the investigated molecules and antioxidant proteins [27].…”