Synthesis of new spiro‐[isothiochromene‐3,5′‐isoxazolidin]‐4(1H)‐ones

Abstract

A series of seven new 2′,3′,4′‐substituted spiro[isothiochromene‐3,5′‐isoxazolidin]‐4(1H)‐ones (7‐13) has been prepared in the reaction of benzylidene(phenyl)azane oxide (5) or benzylidene(methyl)azane oxide (6) with (3Z)‐3‐(4‐substituted‐benzylidene)‐1H‐isothio‐ chromen‐4(3H)‐one (1‐4). The reaction occurs by a 1,3‐dipolar cycloaddition mechanism that leads to the regiospecific formation of various spiroisoxazolidines (7‐13).

Design and synthesis of triazole Schiff bases and their oxovanadium(IV) complexes as antimicrobial agents

“…An important program, Osiris, is available online. With our recent publication of the drug design combination of various pharmacophore sites by using spiro-heterocyclic structure, it is now possible to predict activity and/or inhibition with increasing success in bacteria and HIV [58]. This is done using a combined electronic/structure docking procedure, an example is given in table 7.…”

Structural and theoretical studies of 4,4'-[1,4-phenylene-bis-(azanediyl)]dipent-3-en-2-one: evidence of a π-delocalized keto-enamine

“…To the best of our knowledge limited information on these data points are available for the compounds investigated herein. The B3LYP/6-31G* basis set has been shown to adequately reproduce vibrational frequencies for large scale systems to a reasonably good level of approximation 9,[17][18][19] . We attempted a test calculation at the B3LYP/6-311++G** level of theory and as a result the differences in energies and vibrational frequencies for the 3b/3f separation are minimal.…”