Synthesis of new pyrazolone and pyrazole-based adamantyl chalcones and antimicrobial activity

Abstract

Chalcones and their derivatives are becoming increasingly popular due to their various pharmacological effects. Chalcone molecules may be extracted from natural resources, entirely synthesised, or biosynthesised by modifying the natural ones. In this study, five pyrazole based adamantyl heterocyclic compounds were synthesised by condensation of 1-adamantyl chalcone with substituted phenylhydrazine. The products were characterised by using ¹HNMR, ¹³CNMR and FT-IR spectroscopy. The microbiological activity of these compounds was investigated against bacteria and fungi. The new compounds showed good to moderate activity against the microbial species used for screening. All developed molecules showed antibacterial activity against gram-negative and gram-positive. These molecules showed antifungal activities against Fusarium oxysporum fungus and in a dose-dependent manner, apart from RS-1 molecules which showed compromised antifungal activity and even at a high dose.

Synthetic and computational efforts towards the development of peptidomimetics and small-molecule SARS-CoV 3CLpro inhibitors

“…A major class of heterocyclic compounds that exist in many drugs and synthetic products are pyrazolone derivatives 91 . Such molecules has excellent analgesic 91 , antituberculosis 93 , antifungal 92 , antimicrobial 93 , anti-inflammatory 94 , antioxidant 96 and anti-tumor functions 97 . The pyrazolone structure plays an important role because of its easy preparation and rich biological activity and represents a fascinating template for combinatorial and medicinal chemistry.…”

A Glimpse of the Molecule Chalcone

“…A total of 0.0028 mol of pyridine-2-carboxaldehyde is added to the solution and stirred at room temperature for 48 h. The adamant chalcone is obtained; the reaction mixture is poured into ice water until solid yellow crystals are formed. Then, the system is iltered and washed with a mixture of ethyl acetate: hexane (2:5) several times and dried at room temperature [22]. The progress of the reaction and the extent of purity is monitored by the process of the TLC method.…”

Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis

“…The growth of antimicrobial resistance due to wide misuse and poor patient compliance is causing concern on a global scale. Antimicrobial resistance is a public health challenge that has significant financial and societal effects [ 37 , 38 ]. A serious crisis in the management of infectious illnesses is yet to emerge along with the slowing rate of the development of new antibiotics.…”