Synthesis of new pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidine and study of the pyrazolic nitrogen reactivity

Abstract

A convenient route to the synthesis of pyrazolo [3,4-b]pyridin-3-one and pyrazolo[1,5-a]pyrimidin-2(1H)-one via condensation of 3-amino-1-phenylpyrazolin-5-one with 2-pyrone derivatives followed by the alkylation of prepared compounds is described. Several reactions conditions were carefully studied.