“…Scheme 3. i: Bromoacetyl bromide, TEA, CH 2 Cl 2 ; ii: 7, TEA, CH 2 Cl 2 ; iii: H 2 , Pd/C, methanol; iv: C 60 , paraformaldehyde, toluene, â To better evaluate the effect of fullerene derivative 3 as a neuroprotecting agent, the branched chain without C 60 (16) was synthesized for use as a control in the biological assays (Scheme 4). Scheme 4. i: 13, TEA, CH 2 Cl 2 ; ii: H 2 , Pd/C, methanol; iii: HCl, methanol Derivative 13 was used as alkylating agent with N-(benzyloxycarbonyl)-2,2Đ-bis(ethylenedioxydiethylene)-diamine (17) [21] to obtain 18, which gave 19 after hydrogenolysis. Total deprotection of 19 by HCl/methanol afforded the desired triamino compound 16 as its hydrochloride salt.…”