Synthesis of New Polyheterocyclic Ring Systems Derived from 3-Amino-5-bromo-4,6-dimethyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine

Abdel‐Latif, Ehab; Mehdhar, Fatima S.; Ghani, Ghada E. Abd El

doi:10.1080/10406638.2019.1584574

Cited by 4 publications

(3 citation statements)

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“…[40] Pyranopyrazole compounds are important group of heterocyclic compounds with numerous biological activities. [41] In addition, pyranopyrazoles have also a significant role in agrochemical research due to their fungicidal, bactericidal, and herbicidal properties. [42,43] In order to synthesize these heterocycles, several synthetic approaches have been reported.…”

Section: Chemistryselectmentioning

confidence: 99%

“…several drugs currently on the market, have the pyrazole ring as the key structural motif, [39] and, at this time, several drugs that have pyrazoles in their structure have been approved for the treatment of different types of cancer [40] . Pyranopyrazole compounds are important group of heterocyclic compounds with numerous biological activities [41] . In addition, pyranopyrazoles have also a significant role in agrochemical research due to their fungicidal, bactericidal, and herbicidal properties [42,43] .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano^[2,3]pyrazole Derivatives

2022

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In this study, we presented a description of designing and synthesizing an original nano‐N‐sulfonated (‐SO3H) phthalocyanine molten salt (vanadium‐oxo pyridiniumporphyrazinato sulfonic acid) [VO(TPPASO3H)]Cl as a recyclable and efficient heterogeneous catalyst with thermal stability for synthesizing pyrazole and dihydropyrano[2,3]pyrazole derivatives. After recycling and reapplying five times, this catalyst indicated no significant decrease in the catalytic activity.

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Section: Chemistryselectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano^[2,3]pyrazole Derivatives

2022

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“…Compound 52 ( Figure 18 ) has been found to have an excellent DYRK1B inhibitory enzymic activity with an IC 50 = 3 nM, cell proliferation inhibitory activity (IC 50 = 1.6 μM) against HCT116 colon cancer cells, and inhibitory activity in a patient-derived colon cancer organoids model and a 3D spheroids assay model of SW480 and SW620 [ 18 , 19 ].…”

Section: Biomedical Applications Of 1 H -Pyrazolo[...mentioning

confidence: 99%

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

et al. 2022

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Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds.

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Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis

Alam Mondal,

Ghosh

2024

ChemistrySelect

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Over the last three decades, owing to labour cost, time and especially environmental issues, one‐pot synthesis of heterocyclic compounds involving tandem or multicomponent (sequential or consecutive) reactions has gained particular attention worldwide. Most of the marketed drug molecules hold one or more heterocyclic rings. Due to some side effects of several drugs along with the gradual emergence of antimicrobial resistance, the necessity for developing new heterocyclic molecules continues; special attention should be paid in this respect towards employing more one‐pot reactions for their syntheses. Pyrazolopyridines are fused heterocycles holding pyridine and pyrazole and possess a wide variety of biological and pharmaceutical properties. Several existing drug molecules also bear pyrazolopyridine scaffolds. The present perspective is an endeavour to encompass green syntheses of different isomeric pyrazolopyridine systems, most of these published during the past five years or more for a few cases.

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Synthesis of New Polyheterocyclic Ring Systems Derived from 3-Amino-5-bromo-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine

Cited by 4 publications

References 12 publications

Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano^[2,3]pyrazole Derivatives

Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano^[2,3]pyrazole Derivatives

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis

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Synthesis of New Polyheterocyclic Ring Systems Derived from 3-Amino-5-bromo-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine

Cited by 4 publications

References 12 publications

Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano[2,3]pyrazole Derivatives

Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano[2,3]pyrazole Derivatives

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis

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Product

Resources

About

Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano^[2,3]pyrazole Derivatives

Synthesis and Application of Nano Vanadium‐Oxo Pyridiniumporphyrazinato Sulfonic Acid for Synthesizing Pyrazole and Dihydropyrano^[2,3]pyrazole Derivatives