Synthesis of New Multibenzo Oxygen–Sulfur Donor Macrocycles Containing Lactams at Room Temperature

Abstract

Some new oxygen-sulfur, multibenzo macrocyclic ligands containing amide groups have been prepared using the macrocyclization process with the reaction of 2,2 -thiobis-[4-methyl(2-aminophenoxy)phenyl ether] as a symmetrical diamine with appropriate dicarboxylicacid dichlorides in moderate yields. This macrocyclization led to the formation of diand tetramide macrocycles. These reactions were routinely carried out at ambient temperature in CH 2 Cl 2 as solvent in high dilution without template effect conditions. It is found that sulfur the atom affects the rigidity of the macrocycles and diastereotopicity of nuclei in the ring of these series of macrocyclic compounds.

Macrocyclic Assembly: A Dive into the Pecking Order and Applied Aspects of Multitalented Metallomacrocycles

“…These reactions were routinely carried out at ambient temperature in CH 2 Cl 2 as solvent in high dilution without template effect conditions. It is found that sulfur atom affects the rigidity of the macrocycles and diastereotopicity of nuclei in the ring of these series of macrocyclic compounds [69].…”

2,2'-Thio-bis[(4-methylphenyl)-2-aminobenzoate]

“…In our previous work, we have described the synthesis of new bis-Betti bases [10] and new multibenzo oxygen-sulfur donor macrocycles containing lactams [11] from dibenzosulfide (2) and diamine (3), respectively. In the present study, we report the synthesis of a new bisamine containig a dibenzosulfide moiety.…”