Abstract:Synthesis of New MKC-442 Analogues Containing Alkenyl Chains orReactive Functionalities at C-5.-In an effort to obtain more insight into the interaction between HIV-1 reverse transcriptase (RT) and MKC-442 analogues, a series of new compounds is synthesized and evaluated for inhibition of HIV-1 replication. The modifications include bulky alkenyl substituents at the C-5 position of the uracil ring like in (III) or in the corresponding N-alkylated derivatives (V), (IX), and (XI). Uracils, e.g. (VI) and (XII) w… Show more
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