Synthesis of New Mannich Products Bearing Quinoline Nucleous Using Reusable Ionic Liquid and Antitubercular Evaluation

Abstract

A series of Mannich products bearing quinoline nucleus was synthesized, characterized, and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H 37 Rv. The results showed that compounds 4b, and 4d found most active with percentage inhibition of 95, and 96, respectively, at minimum inhibitory concentration (MIC) of >6.25 µg/mL, among the synthesized compounds. Whereas, compounds 4a, 4c, 4e, and 4f exhibited considerable antitubercular activity with percentage inhibition of 71, 79, 55, and 68, respectively, at MIC of >6.25 µg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, 1 H NMR, 13 C NMR, mass and elemental analysis.

Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones

“…Catalyst-free synthesis of THPQs were also reported using absolute ethanol, 32 acetic acid, 33–35 and electrolysis in presence of alcohol. 36 In continuation of our work in multicomponent synthesis, 37–42 here, we reported the simple acetic acid-mediated multicomponent synthesis of novel PQs. This simple protocol generated 2,4-dimethoxy-THPQs 4(a–d) with good yield of products (68–73%).…”

Microwave-assisted multicomponent synthesis of antiproliferative 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones

“…1e). 26–32 2,4-dimethoxy-THPQs were then evaluated for in vitro antiproliferative activity against six human tumour cell lines. Furthermore, the most potent 2,4-dimethoxy-THPQs are evaluated by in silico ADMET and drug-likeness properties.…”

Catalyst-Free, Room-Temperature Accessible Regioselective Synthesis of Spiroquinolines and Their Antioxidant Study

“…Highly volatile solvents often cause fires and/or detonations, resulting in destruction. Therefore, the attempt made to explore organic synthesis in aqueous solvents, deep eutectic solvents, and ionic liquids are in high demand. − The reactions which lead to successful conversion in aqueous media are gaining much more attention in synthetic organic chemistry not only because water is abundant in nature but due to extensive hydrogen bonding, inexpensive, environmentally benign, high dielectric constant, non-flammability, eco-compatibility, and selectivity in many organic reactions than conventional organic solvents. − …”