Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development

Abstract

Benzothiazole scaffolds exhibit exciting medicinal properties including anticancer. In recent time most complicated job for every researcher is to discover a novel drug that can treat cancer with minimal side effects. Some heterocyclic anticancer drugs including daunorubicin, 5-flourouracil, doxorubicin, methotrexate, etc. are markedly available. In addition, few natural products such as vincristine alongwith vinblastine are used as anticancer drugs. More than 90% of the novel drugs bearing heterocyclic moieties have always been main portions in the development of anticancer drugs. Heterocyclic compounds containing benzothiazole moiety show a superior pharmaceutical effect than non-nitrogen compounds. These N-/S-containing benzothiazole compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in our living cells. This chapter recites the weightage of benzothiazole nuclei in the progress of anticancer drugs.