Synthesis of New Five Coordinated Copper(II) and Nickel(II) Complexes of L‐Valine and Kinetic Study of Copper(II) with Calf Thymus DNA

Abstract

ABSTRACT

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn2 Complex in Human Neuroblastoma Cells

“…Apart from the absence of signal at 10.0−12.0 ppm due to the deprotonation of the carboxylic acid group of l -tryptophan, the 1 H NMR spectra of complexes also exhibited the signals of a NH 2 group of amino acid at ∼5.3 ppm, indicating the coordination of amino acid in a unidentate manner to the zinc atom . Coupled with these observations, the characteristic signals at 4.3, 3.3, 6.9, and 7.1 ppm corresponding to asymmetric CH, CH 2 , imodazole NH, and CHC groups, respectively, further confirmed the presence of l -tryptophan moiety in chiral metal complexes 3 and 4 . , The resonance at ∼7.3 ppm arises due to the -NH proton of 1,2-diaminobenzene . This feature is commensurate with the fact that the amino group of 1,2-diaminobenzene was coordinated to the Sn/Zr metal ion through monodeprotonation and simultaneously to the zinc metal atom.…”

“…observations, the characteristic signals at 4.3, 3.3, 6.9, and 7.1 ppm corresponding to asymmetric CH, CH 2 , imodazole NH, and CHdC groups, respectively, further confirmed the presence of L-tryptophan moiety in chiral metal complexes 3 and 4. 24,25 The resonance at ∼7.3 ppm arises due to the -NH proton of 1,2-diaminobenzene. 26 This feature is commensurate with the fact that the amino group of 1,2diaminobenzene was coordinated to the Sn/Zr metal ion through monodeprotonation and simultaneously to the zinc metal atom.…”

Synthesis, characterization, thermal, anticancer studies, and density functional theory for potentially active pyrimidine‐based complexes

“…The absorption spectral bands showed bands at 518, 659, and 1020 nm corresponding to 3 B(F) → 3 E(P), 3 B(F) → 3 A 2 (P), and 3 B(F) → 3 E(P) transitions in the Ni(II) complex, respectively. This implied a square pyramidal structure surrounding the Ni(II) ion, and the value of the magnetic moment was reported as 2.57 BM 38 . The square planar shape of Cu(II) ion was elucidated by the electronic transitions of 2 B 1g → 2 A 1g , 2 B 1g → 2 Eg, and 2 B 1g → 2 B 2g , respectively, lying at 563, 668, and 719 nm.…”

“…This implied a square pyramidal structure surrounding the Ni(II) ion, and the value of the magnetic moment was reported as 2.57 BM. 38 The square planar shape of Cu(II) ion was elucidated by the electronic transitions of 2 B 1g ! 2 A 1g , 2 B 1g !…”