Synthesis of New Bis-1,2,4-Triazole Derivatives

Abstract

A series of new 1,2/1,3-bis[o-(N-methylidenamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 4 were prepared in good yields by treatment of 4-amino-3-aryl-5-phenyl-4H-1,2,4-triazoles 2 with certain bis-aldehydes 1. Compounds 4 were reduced with NaBH 4 to afford the corresponding 1,2/1,3-bis[o-(Nmethylamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 5. All new compounds were characterized by IR, 1 H-NMR, 13 C-NMR and mass spectral data.

Synthesis, Characterization and Pharmacological Screening of Some Substituted 1,2,3- & 1,2,4-Triazoles

“…The infrared spectra of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) showed the characteristic absorption bands of >C=N and C-N of triazole ring at 1562-1598 cm -1 and 1313-1365 cm -1 respectively, which confirmed the formation of triazole ring.…”

“…The biological profile of triazoles derivatives is very extensive [1][2][3] . Compounds bearing a symmetrical triazole moiety are reported to show a broad spectrum of pharmacological activities such as antibacterial [4][5][6][7] , antifungal [8][9][10][11] , antimicrobial [12][13][14] , antimycobacterial [15][16] , antioxidant 17 , analgesic 18,19 , antipyretic 20 , anticancer [21][22] , anticonvulsant 23 and anti-inflammatory [24][25][26] activities.…”

Microwave assisted synthesis, spectroscopic and antibacterial studies of titanocene chelates of Schiff bases derived from 3-substituted-4-amino-5-hydrazino-1,2,4-triazoles

“…Several compounds containing 1,2,4-triazole rings are well known for drugs [1]. 1,2,4-triazoles containing amino groups are also of importance for obtaining various Schiff base derivatives with well known antimicrobial properties [8][9][10].…”

“…1,2,4-triazoles and their derivatives are associated with various biological activities, such as anticonvulsant, antifungal, anticancer, antiinflammatory and antibacterial properties [1][2][3][4][5][6][7]. Several compounds containing 1,2,4-triazole rings are well known for drugs [1].…”

Synthesis and antimicrobial evaluation of some 1,2,4-triazolo[1,5-a]pyridine, pyrimidine sulfonamides and sulfinyl derivatives

“…They were shown to be effective as anti-inflammatory, antibacterial, anticonvulsant, dephlogisticate, anti-depressant, antifungal, anticancer, antibacterial properties, antipyretic, and antifungal agents [29][30][31][32]. Pyridyl methyl sulfinyl benzimdizole derivatives such as omeprazole, rebeprazole, lansoprazole, pantoprazole, esomptazol are the drug of choice for the acid related gastrointestinal disorders.…”