Synthesis of New Benzofuran-Pyrazole Hybrids as Potential Antibiofilm Agents

Lingaraju, Gejjalagere S.; Somashekaraiah, Rakesh; Kumar, Koravangala S.V.; Rao, K. Penta; Sreenivasa, M. Y.; Sadashiva, M. P.

doi:10.2174/1570180813666160923170414

Cited by 4 publications

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“…EPS extremely increases microbial resistance by preventing the passage of antibiotics and other harmful substances into the bacterial community [3]. Unfortunately, bacteria within biofilms are responsible for causing about 80–90% of infections in humans and are more adaptively resistant to antibiotic treatment [4]. Therefore, a variety of antibiotics have been used for the treatment of infections but biofilm formation decreases its efficacy and produce enormous adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antibacterial evaluation of N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amine derivatives

Shruthi

Kiran

Divyashree

et al. 2022

Journal of Heterocyclic Chem

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A series of substituted N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amines (5a–j) (5ab, 5ac) were synthesized in good yield and characterized for their structural confirmation. The pure quinoxaline products were screened for their in‐vitro antibacterial activity against Salmonella paratyphi, a well‐known food borne pathogen. The preliminary results revealed that among the series, compounds 5a, 5c, 5d, 5e, 5f, 5h, 5ab and 5ac bearing bromo, fluoro, methoxy, methyl groups at para position on phenyl ring which inturn substituted at third position of quinoxaline and methyl, benzoyl groups at sixth position on the quinoxaline were emerged as potential candidates by displaying antisalmonella activity. Among the potential candidates, compounds 5c, 5e, 5f and 5ac were effective against Salmonella whereas compounds 5a, 5f and 5ac effectively inhibited the biofilm formation of Salmonella.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antibacterial evaluation of N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amine derivatives

Shruthi

Kiran

Divyashree

et al. 2022

Journal of Heterocyclic Chem

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Novel bis(pyrazole-benzofuran) hybrids possessing piperazine linker: Synthesis of potent bacterial biofilm and MurB inhibitors

Mekky

Sanad

2020

Bioorganic Chemistry

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Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents

Zhou

et al. 2022

CTMC

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: Gram-positive and Gram-negative pathogens are able to evade the host immune system, persist within the human host, and lead to severe disease and even death. At present, bacterial infections are one of the leading causes of morbidity and mortality across the world. Development of novel antibacterial agents still represents a challenging endeavor, which is mainly attributed to the continuous emergence of more virulent and drug-resistant pathogens. Benzofuran constitutes the core of diverse pharmacologically active compounds, and there are a variety of approved benzofuran-based drugs in the market or currently going through different clinical phases or registration statuses. Benzofurans could exert antibacterial activity through various mechanisms and possess pronounced activity, so benzofuran is a useful skeleton for the discovery of novel antibacterial agents. This review focuses on the recent advancement of naturally occurring benzofuran derivatives and hybrids of benzofurans with other pharmacophores as antibacterial agents, covering articles published between January 2015 and July 2021. The chemical structures and structure-activity relationships are also discussed.

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Synthesis of New Benzofuran-Pyrazole Hybrids as Potential Antibiofilm Agents

Cited by 4 publications

References 0 publications

Synthesis, characterization and antibacterial evaluation of N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amine derivatives

Synthesis, characterization and antibacterial evaluation of N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amine derivatives

Novel bis(pyrazole-benzofuran) hybrids possessing piperazine linker: Synthesis of potent bacterial biofilm and MurB inhibitors

Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents

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