Synthesis of new 6- and 8-Alkenyl-3,7,3’,4’-Tetramethoxyquercetin derivatives by microwave-assisted Heck coupling

Total Synthesis of Mulberry Diels–Alder-Type Adducts Kuwanons G and H

“…Eventually, careful experimentation revealed that the reaction works best using (PCy 3 ) 2 PdCl 2 as the catalyst in toluene at 60 °C in the presence of the base K 3 PO 4 in 41% yield. 22,23 It was found that diene 5 was unstable and should be immediately used in the next step after rapid purification.…”

“…With PdCl 2 , Pd­(PPh 3 ) 4 , Pd 2 (dba) 3 , and Pd­(OAc) 2 as the palladium catalysts, either no expected product was detected or the reactivity decreased in toluene. Eventually, careful experimentation revealed that the reaction works best using (PCy 3 ) 2 PdCl 2 as the catalyst in toluene at 60 °C in the presence of the base K 3 PO 4 in 41% yield. , It was found that diene 5 was unstable and should be immediately used in the next step after rapid purification.…”