Synthesis of new 4-methylesculetin complexes as anti-neoplastic agents and X-ray structure of dimeric bis-bipyridyl-bis-4-methylesculetinato zinc(II)

Butler, Ian S.; Gilson, D. F. R.; Jean‐Claude, Bertrand J.; Mostafa, Sahar I.

doi:10.1016/j.ica.2014.05.048

Cited by 14 publications

(1 citation statement)

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“…The need to develop new complexes with reduced nephrotoxicity and higher activity has stimulated the synthesis of many new complexes. Over the past years, a renewed interest in Zn(II), Ag(I), Pd(II) and Pt(II) complexes as potential anticancer agents has developed in our laboratory [40,44,[49][50][51][52][53][54][55]. We have reported earlier the anticancer activity of 6-methylpyridine-2-carbaldehyde-N(4)-phenylthiosemicarbazone (Hmpyptsc) and its complex, [Zn(Hmpyptsc)Cl 2 ], against human colon cancer (HCT116) and prostate cancer (DU145) cell lines [54].…”

Section: Anticancer Activitymentioning

confidence: 99%

Synthesis, characterization and anticancer activity of 3-formylchromone benzoylhydrazone metal complexes

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Butler

Claude

et al. 2014

Transition Met Chem

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A new Schiff base derived from 3-formylchromone and benzohydrazide (Hfcbh) and its Ni(II), Zn(II), Ru(II), Ru(III), Pd(II), Pt(II) and Ag(I) complexes were synthesized. These compounds were characterized on the basis of physicochemical and spectroscopic methods. Two modes of chelation for Hfcbh are reported: (1) neutral tridentate ligand through the chromone carbonyl oxygen, hydrazonic carbonyl oxygen and azomethine nitrogen atoms and (2) mononegative tridentate ligand via the chromone carbonyl oxygen, hydrazonic deprotonated hydroxy oxygen and azomethine nitrogen atoms. Free Hfcbh and its Ni(II), Zn(II), Ag(I), Pd(II) and Pt(II) complexes have been tested as anticancer agents against the human breast cancer (MDA-MB231) and human ovarian cancer (OVCAR-8) cell lines. The [Ag(fcbh)(PPh 3 )] complex shows the highest efficacy with a mean IC 50 values of 1.0 (MDA-MB231) and 0.87 (OVCAR-8) lM, respectively.

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