Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents

Abstract

2-(3-(1H-Indol-3-yl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-substituted-5-(substituted diazenyl)thiazoles and 2-(1H-indol-3-yl)-9-substituted-4,7-disubstituted pyrido [3,2-e]

Synthesis, in‐vitro and in‐silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors

“…On the contrary, several publications reported the synthesis of 2‐hydrazineylthiazole derivatives [ 7–9 ] because they exhibit an important role in medicinal chemistry, [ 10 ] such as antibacterial and antifungal agents, [ 11–13 ] as well as inhibitors for bacterial DNA gyrase B. [ 14 ] Several thiazoles exhibit promising antibacterial activities by their inhibition of the MurB enzyme, which is responsible for the biosynthesis of bacterial cell walls.…”

Highly Efficient [3 + 2] Cycloaddition: Click Synthesis of Novel 1H‐indol‐3‐yl‐benzo[d]imidazole Bis‐triazoles

“…Indoles are one of the most important nitrogen‐containing heteroaryl compounds, found extensively in biological systems such as tryptophan which play a very important role in biochemical processes. Because the wide range of biological activities is associated with indole derivatives, both naturally occurring and synthetic indole derivatives remain a topic of current interest . Among the wide variety of heterocycles that have been explored for developing biochemically important molecules, benzimidazoles played an important role in medicinal chemistry , and the scaffolds of benzimidazole containing indole moieties always attract the attention of chemists .…”

Crystal structure of N′-(1-(benzofuran-2-yl)ethylidene)-2-cyanoacetohydrazide, C13H11N3O2

“…N′(-(Heterocycle)ethylidene)-2-cyanoacetohydrazides have been used as precursors for the synthesis of various biologically active heterocycles[5][6][7][8]. The crystal structures for various hydrazides have been recently reported[9][10][11].The asymmetric unit consists of one molecule of the title compound.…”