Synthesis of new 2-oxonicotinic acids

Abstract

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by ternary condensation of Meldrum's acid with triethyl orthoformate and aniline, reacts with N-aryl cyanoacetamides in the presence of KOH to give 2-oxo-1,2-dihydropyridine-3-carboxylic acids, which are useful as drug precursors or perspective ligands.