Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Imidazolium‐based poly(ionic liquid)s with poly(ethylene oxide) main chains: Effects of spacer and tail structures on ionic conductivity

“…Sodium azide, ethylene diaminetetraacetic acid disodium salt (EDTA·2Na) and sodium iodide (NaI) were purchased from Nakarai Tesque. α‐Chloro‐ω‐propargyl‐di(ethylene glycol), α‐chloro‐ω‐propargyl‐tri(ethylene glycol), GAP, and the model polymer of glycidyl 4‐benzyl‐1,2,3‐triazole polymer (GTP‐C‐Ph) were synthesized according to the literature …”

18F-Labeled Silicon-Based Fluoride Acceptors: Potential Opportunities for Novel Positron Emitting Radiopharmaceuticals

“…An initial study by Bohn et al and a follow-up investigation by Joyard et al demonstrated the synthesis, radiolabeling, and in vivo evaluation of silicon-based analogues of [ 18 F]FMISO, an established tracer for detection of hypoxia [62, 63]. In spite of the well-known steric requirements of the silicon atom, the authors described a series of alkyl substituted [ 18 F]SiFA-FMISO analogues which resulted in insufficient hydrolytic stability both in vitro and in vivo (Table 3; Entries 1 and 2).…”

Facile and Efficient Synthesis of [18F]Fluoromisonidazole Using Novel 2-Nitroimidazole Derivatives

“…2,3 Due to these features, identification and quantitative assessment of tissue hypoxia is a significant factor for optimal therapy outcome. 4 Diverse invasive and non-invasive methods using various modalities are available to measure hypoxia in tumors. 5 Despite many invasive techniques available to assess tissue hypoxia, there are some limitations such as technical complexity, erratic results and impossibility of repetitive measurements.…”

“…8 High resolution images of PET are obtained by 18 F that has ideal physical properties such as a half-life of 110 min and a low-energy positron of 640 keV. 4 Nitroimidazole is generally employed and studied as an exogenous marker for tumor hypoxia, due to its unique property in hypoxic environments related to the reduction of its nitro group. [9][10][11][12][13] Reactive intermediates that accumulate in hypoxic tissues through binding to cellular constituents are generated by a reversible reduction step in normoxic cells but not hypoxic cells.…”