volume 81, issue 19, P8911-8919 2016
DOI: 10.1021/acs.joc.6b01460
View full text
Liyao Zheng, Yunhui Bin, Yunpeng Wang, Ruimao Hua

Abstract: An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was developed. Also, a general strategy for modular construction of polyheterocycles with diverse natural product-like skeletons was developed by using ketone-alkyne bifunctional substrates. These reactions involved a one-pot cascade oximation of ketones, rhodium-catalyzed C-H activation, and intermolecular/intramolecular alkyne an…

expand abstract