Synthesis of N-Substituted (Z)-3-Arylbenzo[c]thiophen-1(3H)-imines by the Reaction of 1-[Aryl(methoxy)methyl]-2-lithiobenzenes with Isothiocyanates Followed by Acid-Mediated Cyclization

Abstract

The title transformation provides benzothiophenimines some of which are further hydrolized to the corresponding benzothiophenones.

TiCl4-Mediated Preparation of Thiophthalide Derivatives via Formal Thio-Passerini Reactions

“…Whereas these compounds are typically synthesized through multistep processes or by nucleophilic additions onto thiophthalic anhydride, ,,, the restricted available methods for their preparation have most likely hampered their use in medicinal chemistry. Accordingly, in order to allow a more thorough evaluation of the pharmacological potential of this so far overlooked chemical space, the development of new synthetic methods is highly desirable.…”