Synthesis Of N, N′‐Bis(8‐Quinolyl)‐Oligo‐Methylene‐Diamines from 8‐Aminoquinolines

Abstract

Various N′,N‐bis(8‐quinolyl) trimethylenediamines 3a‐3e have been prepared from the corresponding 8‐aminoquinolines 1a‐1e by direct N‐alkylation with 1, 3‐dibromopropane in fair yield (25‐51%). N. N′‐bis(8‐quinolyl) ethylenediamines, 3f and 3g, and N,N′‐bis(8‐(6‐methoxyquinolyl) ]tetramethylenediamine. 3h, may only be synthesized in poor yield via the corresponding oxalamides and succinamide.