Synthesis of N-doped carbon quantum dots from bio-waste lignin for selective irons detection and cellular imaging

Shi, Yixin; Liu, Xin; Wang, Meng; Huang, Jianbo; Jiang, Xueqin; Pang, Jinhui; Xu, Feng; Zhang, Xueming

doi:10.1016/j.ijbiomac.2019.01.146

Cited by 134 publications

(53 citation statements)

References 60 publications

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“…The presence of hydrophilic groups, such as hydroxyl, carboxyl, and amino groups, is responsible for the excellent water solubility of the prepared CQDs. The results correspond to other researcher's data [6,8,43,44].…”

Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupsupporting

confidence: 90%

“…The first one, around 200 nm, comes from the π → π* transitions of C=C groups which are caused by the sp2 hybridization of the C atoms [2], whereas the peaks at 293 nm (Dot-2), 298 nm (Dot-3), 301 nm (Dot-1), and 301 nm (Dot-4) corresponds to n → π* transitions of C=O groups [2,38,39,43]. The UV-VIS spectrum is typical for carbon quantum dots and two different surface states can be distinguished which agrees with the data obtained by other researchers [2,6,8,43]. The UV-VIS results correspond to the FTIR spectra ( Figure 3) which showed bands typical for unsaturated carbon-carbon bonds as well as free carboxylic groups.…”

Section: Morphology Studysupporting

confidence: 80%

“…A promising tool are quantum dots (QDs) which can be described as objects of the size below 10 nm with unique properties [1][2][3][4]. Since their development, they have been successfully used in optoelectronics [1], food packaging [5], metals detection [6][7][8], bioimaging [9][10][11][12][13][14], photocatalysis [15,16], sensing [17][18][19][20][21][22][23], cell labelling [24], or fluorescent inks and others [25,26]. The first-generation quantum dots are semiconductors of crystalline structure [3].…”

Section: Introductionmentioning

confidence: 99%

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Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

et al. 2020

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Carbon quantum dots (CQDs) are nanoobjects of a size below 10 nm. Due to their favorable features, such as tunable luminescence, unique optical properties, water solubility, and lack of cytotoxicity, they are willingly applied in biomedicine. They can be obtained via bottom-up and top-down methods. However, to increase their quantum yield they must undergo post-processing. The aim of the following research was to obtain a new type of CQDs modified with a rhodamine b derivative to enhance their fluorescence performance without biocompability deterioration. For their preparation glucose was used as a precursor and four different carbonizing agents which affected semi-and final products luminescence properties. The ready nanomaterials were investigated over their chemical structure by FTIR and NMR, whereas morphology was investigated by the TEM method. Their optical properties were determined by UV-VIS spectroscopy. Fluorescence behavior, photo-and pH-stability, as well as solvatochromism showed their applicability in various biomedical applications due to the controlled properties. The samples exhibited excellent antioxidant activity and lack of cytotoxicity on L929 mouse fibroblasts. The results showed that proposed strategy enables preparation of the superior nanomaterials with outstanding luminescence properties such as quantum yield up to 17% which can be successfully applied in cell labelling, bioimaging, and theranostics.Molecules 2020, 25, 736 2 of 18 can release cadmium ions leading to cell death. Importantly, it occurred that quantum dots may undergo certain modifications resulting in the change of their surface or chemical structure [27,28]. Finally, their preparation is expensive. Therefore, there was a need for a novel type of quantum dots which would be suitable for biomedical applications. In 2004, a new type of carbon-based materials was accidentally obtained during nanotube purification [29]. Until then, numerous types of carbon quantum dots (CQDs) have been obtained with various possible applications due to their very attractive properties, such as luminesce, good water solubility, high photostability, resistance to photobleaching or photoblinking, possibility, chemical inertness and, finally, lack of toxicity and biocompability [1][2][3]. Furthermore, CQDs' region of photoluminescence is very broad, starting in the ultraviolet and ending in the near-infrared. Although, until now, the luminescence behavior of carbon nanodots is still not fully clear, it is believed that crucial role plays two factors, namely, that the quantum size is below 10 nm and surface defects which may act as excitation energy traps. Interestingly, CQDs can successfully act as both electron donors and acceptors [2][3][4].CQDs can be prepared from various resources, such as peels (mango, orange, banana, pineapple, onion, seaweed etc.), meat, grains, nuts, or vegetable by-products, which makes them a low-cost material [30,31]. Currently, these nanomaterials are widely applied in drug delivery, gene delivery, biosensing, bioimag...

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Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupsupporting

confidence: 90%

Section: Morphology Studysupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

et al. 2020

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“…The phenomenon may be caused by the presence of graphite nitrogen in the CQDs (Figure 3d), which did not appear in other relevant reports. [40,[42][43][44][45] Graphite nitrogen in CQDsp rovides an excess of electrons for the unoccupied p*o rbitals of the conjugated system,m aking the HOMO!LUMOg ap small (only 2.07 eV) and resulting in aPLr edshift of the CQDs. [52,53] In recenty ears, ion detection based on fluorescent CQDs has been rapidlyd eveloped.…”

Section: Resultsmentioning

confidence: 99%

“…[37][38][39] As an alternative precursor, lignin has been converted to high-valuable nanoscale fluorescent materials in previous work. [25,[40][41][42][43][44][45] For example, Rodríguez-Padróne tal. [41] produced blue fluorescent CQDs by am icrowave-assisted method.…”

Section: Introductionmentioning

confidence: 99%

Sustainable Synthesis of Bright Green Fluorescent Nitrogen‐Doped Carbon Quantum Dots from Alkali Lignin

et al. 2019

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Sustainable, inexpensive, and environmentally friendly biomass waste can be exploited for large‐scale production of carbon nanomaterials. Here, alkali lignin was employed as a precursor to synthesize carbon quantum dots (CQDs) with bright green fluorescence through a simple one‐pot route. The prepared CQDs had a size of 1.5–3.5 nm, were water‐dispersible, and showed wonderful biocompatibility, in addition to their excellent photoluminescence and electrocatalysis properties. These high‐quality CQDs could be used in a wide range of applications such as metal‐ion detection, cell imaging, and electrocatalysis. The wide range of biomass lignin feedstocks provide a green, low‐cost, and viable strategy for producing high‐quality fluorescent CQDs and enable the conversion of biomass waste into high‐value products that promote sustainable development of the economy and human society.

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Nano‐Strategies for Lignin Biomaterials toward Cancer Therapy

Sathasivam

Jiao

Sugiarto

et al. 2023

Adv Healthcare Materials

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Lignin is a nontoxic and biocompatible biopolymer with many promising characteristics, including a high tensile strength and antioxidant properties. This natural polymer can be processed through several chemical methods and modified into lignin nanomaterials for potential biomedical applications. This review summarizes the latest developments in nanolignin (NL)-based biomaterials for cancer therapy; various NL applications related to cancer therapy are considered, including drug and gene delivery, biosensing, bioimaging, and tissue engineering. The manuscript also outlines the potential use of these materials to improve the therapeutic potency of chemotherapeutic drugs by decreasing their dose and reducing their adverse effects. Due to its high surface area-to-volume ratio and the easy modification of its chemical components, NL could serve as an appropriate matrix for the binding and controlled release of various pharmaceutical agents. Moreover, the challenges in the utilization of NL-based materials for cancer therapy are discussed, along with the prospects of advances in such nanomaterials for medical research applications.

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Synthesis of N-doped carbon quantum dots from bio-waste lignin for selective irons detection and cellular imaging

Cited by 134 publications

References 60 publications

Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

Sustainable Synthesis of Bright Green Fluorescent Nitrogen‐Doped Carbon Quantum Dots from Alkali Lignin

Nano‐Strategies for Lignin Biomaterials toward Cancer Therapy

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