Synthesis of multiple boron-containing analogs via Ugi-4CR

Chen, Yiwei; Liao, Pei Chun; Zhang, Yuxuan; Yeh, Shang-Yi; Wu, Yu‐Hsuan; Qiu, Shuo-Bei; Tsai, Pei-Ni; Xin, Zhuo; Ting, Yen-Yu; Chen, Hsien-Chi; Cheung, Siu-Fung; Hsu, Chen-Yun; Lien, Wan-Hsing; Pan, Po-Shen

doi:10.1007/s11164-018-3629-0

Cited by 2 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, the international BNCT medicinal chemistry research and development community has attempted to develop various new promising boron-containing drugs, such as GB-10, boric acid etc. [9][10][11]. If these new boron-containing drugs can be delivered into tumor cells specifically and efficiently, this would form an important basis for the successful clinical treatment implementing BNCT.…”

Section: Development Of New Boron-10-containing Drugs and Breakthroughs In The Concept Of Radiobiologymentioning

confidence: 99%

Boron Neutron Capture Therapy: A New Generation of Targeted Charged-Particle Radiotherapy

Chen

Chou

Huang

et al. 2019

BJSTR

View full text Add to dashboard Cite

Radiation therapy plays an important role in standard cancer treatment. However, patients who are resistant to traditional radiation therapy or who have relapsed after conventional radiation therapy are often encountered in clinical practice. There is therefore a need for a new radiation therapy for this type of patient. Although boron neutron capture therapy is not a new concept of radiation therapy, due to technological breakthroughs and conceptual improvements at the start of the 21 st century, this therapy, which covers multidisciplinary technologies, such as medical physics, atomic science and technology, boron-containing drug synthesis, radiobiology, and clinical oncology has advanced greatly, and has gradually matured to a clinically useful therapy for patients with cancer. This article provides a brief introduction to the latest breakthroughs and progress in this technology.

show abstract

Section: Development Of New Boron-10-containing Drugs and Breakthroughs In The Concept Of Radiobiologymentioning

confidence: 99%