Synthesis of Multifunctional Ag@Au@Phenol Formaldehyde Resin Particles Loaded with Folic Acids for Photothermal Therapy

Abstract

Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting, the nanocomposite consists of an Ag core, an Au layer, a PFR shell, and folic acids on the PFR shell. The Ag@PFR core-shell structure can be prepared with a simple hydrothermal method after preheating. We then filled the PFR shell with a layer of Au by heating and modified the shell with polyelectrolyte to change its surface charge state. To capture tumor cells actively, FA molecules were attached onto the surface of the Ag@Au@PFR particles in the presence of 1-ethyl-3-(3-dimethly aminopropyl) carbodiimide (EDAC) and N-hydroxysuccinimide (NHS). Owing to the excellent property of Au NPs and Ag NPs as photothermal conversion agents, the Ag@Au@ PFR@FA particles can be utilized to kill tumor cells when exposed to NIR light.

Fluorescent glutathione probe based on MnO 2 -phenol formaldehyde resin nanocomposite

“…Recently, Yu's group has reported a one-step hydromental approach of green luminescent phenol formaldehyde resin (PFR) nanoparticles with the characteristic of stable luminescence and good monodispersibility (Guo et al, 2008;Yang et al, 2012a;Yang et al, 2012b). Moreover, PFR nanoparticles are low toxicity in water with controllable size.…”

Synthesis and Characterization of Silver Nanoparticle Modified 3-Aminophenol Resin Microspheres with Application for Determination of Carcinoembryonic Antigens by Surface-Enhanced Raman Scattering

“…Phenolic resins were recently applied in cell imaging (Guo et al 2008), photothermal therapy (P. Yang et al 2012), and gas adsorption (J. Liu et al 2011) because of their excellent biocompatibility, low toxicity, and porosity.…”

Unique Necklace‐Like Phenol Formaldehyde Resin Nanofibers: Scalable Templating Synthesis, Casting Films, and Their Superhydrophobic Property

“…Recently, with the development of nanotechnology, PFR has attracted more attention due to its new great potential application in biological, environmental and energy field. For example, good biocompatibility, fluorescence, and abundant surface functional groups endow the PFR‐based nanomaterials excellent performance in cell imaging, photothermal therapy, and water treatment . In addition, porous carbon derived from pyrolysis of PFR has also widespread application, including catalyst supports, electrode materials for batteries, and supercapacitors .…”