Synthesis of multidentate functional monomer for ion imprinting

Abstract

In this work, N,N,propyl-trimethoxysilane was prepared as a multidentate functional monomer. The 3D model of the monomer coordinating with Cu 2+ indicated that the monomer is able to provide five ligating atoms like ethylenediaminetetraacetic acid-Cu 2+ to complex with Cu 2+ .When Cu 2+ was used as a template ion, the synthesis conditions of Cu 2+ -imprinted polymers were optimized upon orthogonal design. It is interesting to find that Cu 2+imprinted polymer offers a selectivity coefficient of 192.2 when the molar ratio of Cu 2+ to monomer was exactly 1:1. That means there is no excess ligating atom in the ion-imprinted polymer and therefore, the nonspecific adsorption could be avoided.Benefiting from the excellent selectivity of Cu 2+ -imprinted polymer, even if the concentration of Zn 2+ was 25 times that of Cu 2+ , Cu 2+ -imprinted polymer still affords a high selectivity coefficient. Finally, the optimal synthesis conditions for Cu 2+imprinted polymer, except the pH, were adopted to prepare Ni 2+ -imprinted polymer, and Ni 2+ -imprinted polymer also offered satisfying selectivity to Ni 2+ . That implies this multidentate monomer is adaptable in ion imprinting and, the optimal synthesis conditions of Cu 2+ -imprinted polymer except pH are likely suitable for the imprinting of other ions besides Cu 2+ . K E Y W O R D Sion-imprinted polymer, multidentate functional monomer, sol-gel 1356

Selective recognition of tumor cells by molecularly imprinted polymers

“…Followed by the initial application in enantiomeric separation, MIPs were further developed as SPE sorbents for the selective enrichment of trace analytes from complex samples [7][8][9][10][11][12][13][14][15]. The merits of MIPs allowed the extension of the "fishing-out" targets from ions [16][17][18], small molecules [19][20][21][22][23][24][25], peptides [26][27][28], and proteins [29,30] to microorganisms and cells. To date, MIPs have also been synthesized for the specific capture and selective isolation of tumor cells.…”