Synthesis of Multicomponent and Multiblock Copolymers and Their Sustained Release Behavior for Fluorescein Sodium

Wang, Xuan; Li, Fanfan; Zhao, Huanhuan; Zhang, Yanwu

doi:10.1021/acsapm.0c00348

Cited by 4 publications

(3 citation statements)

References 31 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fundamental understandings of the relationship between chemical compositions, physical structural arrangements (e.g., block sequence and the length of each block), and hydrophobicity of the copolymers can guide the rational design of their self-assemblies into the desired and controllable morphology. Research has shown that an increase in the number of blocks generally leads to enhanced mechanical properties in the formation of hydrogels. , It is known that the arrangement of blocks affects the secondary structure, water solubility, , and drug release efficiency . It is therefore anticipated that the block sequence can tune the gelation concentration and sol–gel transition.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 25 It is known that the arrangement of blocks affects the secondary structure, 27 water solubility, 27 , 28 and drug release efficiency. 29 It is therefore anticipated that the block sequence can tune the gelation concentration and sol–gel transition. While little research attention is paid to the block arrangement within the polymer chain, this report hopes to provide the missing piece in the puzzle of the self-assembly multiblock polymer structure in aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels

Wang,

Liu,

Tan

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Peptide-based hydrogels have great potential for applications in tissue engineering, drug delivery, and so on. We systematically synthesize, characterize, and investigate the selfassembly behaviors of a series of polypeptide-based penta-block copolymers by varying block sequences and lengths. The copolymers contain hydrophobic blocks of poly(γ-benzyl-Lglutamate) (PBG, B x ) and two kinds of hydrophilic blocks, poly(L-lysine) (PLL, K y ) and poly(ethylene glycol) (PEG, EG 34 ), where x and y are the number of repeating units of each block, where PBG and PLL blocks have unique functions for nerve regeneration and cell adhesion. It shows that a sufficient length of the middle hydrophilic segment capped with hydrophobic end PBG blocks is required. They first self-assemble into flower-like micelles and sequentially form transparent hydrogels (as low as 2.3 wt %) with increased polymer concentration. The hydrogels contain a microscale porous structure, a desired property for tissue engineering to facilitate the access of nutrient flow for cell growth and drug delivery systems with high efficiency of drug storage. We hypothesize that the structure of B x -K y -EG 34 -K y -B x agglomerates is beyond micron size (transparent), while that of K y -B x -EG 34 -B x -K y is on the submicron scale (opaque). We establish a working strategy to synthesize a polypeptide-based block copolymer with a wide window of sol−gel transition. The study offers insight into rational polypeptide hydrogel design with specific morphology, exploring the novel materials as potential candidates for neural tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels

Wang,

Liu,

Tan

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Fluorescein sodium contains functional groups such as the carboxyl group, carbonyl group, and phenolic hydroxyl group, which are ubiquitous in various drugs and interact with carriers. Because of this, it is often used as a drug model molecule in the studies of drug carriers [28,29]. Moreover, it was proven that fluorescein sodium is a general substrate of the entire human family of organic anion transporting polypeptides, which are transmembrane proteins that influence the pharmacokinetics and drug-drug interactions of several clinically relevant compounds [30].…”

Section: Introductionmentioning

confidence: 99%

On the Solvatochromism of Fluorescein Sodium

Cheptea,

Zara,

Ambrosi

et al. 2024

Symmetry

View full text Add to dashboard Cite

Fluorescein sodium is a very important compound for a wide spectrum of applications, from which medical applications prevail. Despite this, there are very few studies in the literature related to the structure and fundamental properties of fluorescein sodium and its solutions, with most of the studies dealing with fluorescein. The purpose of the present article is to determine some parameters of the fluorescein sodium molecule approaching the quantum-mechanical modeling and experimental solvatochromism in both binary and ternary solutions. For data analysis, several theoretical models were applied. The results highlight the intermolecular interactions involved in the spectral shift of the electronic absorption band of fluorescein sodium when dissolved in different solvents or binary solvents and allowed the estimation of the difference between the interaction energy in molecular pairs of the type of fluorescein sodium − solvent 1 and fluorescein sodium − solvent 2. By applying a variational method, the dipole moment in the first excited state of the fluorescein sodium molecule and the angle between the dipole moments in the ground and excited states, respectively, were estimated. These results are useful for a better understanding of the behavior of fluorescein sodium when dissolved in different solvents or combinations of solvents, to develop new practical applications.

show abstract

Thermoresponsive and co-nonsolvency behavior of poly(N-vinyl isobutyramide) and poly(N-isopropyl methacrylamide) as poly(N-isopropyl acrylamide) analogs in aqueous media

et al. 2023

View full text Add to dashboard Cite

Sets of the nonionic polymers poly(N-vinyl isobutyramide) (pNVIBAm) and poly(N-isopropyl methacrylamide) (pNIPMAm) are synthesized by radical polymerization covering the molar mass range from about 20,000 to 150,000 kg mol−1, and their thermoresponsive and solvent-responsive behaviors in aqueous solution are studied. Both polymers feature a lower critical solution temperature (LCST) apparently of the rare so-called type II, as characteristic for their well-studied analogue poly(N-isopropyl acrylamide) (pNIPAm). Moreover, in analogy to pNIPAm, both polymers exhibit co-nonsolvency behavior in mixtures of water with several co-solvents, including short-chain alcohols as well as a range of polar aprotic solvents. While the cloud points of the aqueous solutions are a few degrees higher than those for pNIPAm and increase in the order pNIPAm < pNVIBAm < pNIPMAm, the co-nonsolvency behavior becomes less pronounced in the order pNIPAm > pNVIBAm > pNIPMAm. Exceptionally, pNIPMAm does not show co-nonsolvency in mixtures of water and N,N-dimethylformamide. Graphical Abstract

show abstract

Synthesis of Multicomponent and Multiblock Copolymers and Their Sustained Release Behavior for Fluorescein Sodium

Cited by 4 publications

References 31 publications

Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels

Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels

On the Solvatochromism of Fluorescein Sodium

Thermoresponsive and co-nonsolvency behavior of poly(N-vinyl isobutyramide) and poly(N-isopropyl methacrylamide) as poly(N-isopropyl acrylamide) analogs in aqueous media

Contact Info

Product

Resources

About