Synthesis of monosized core–shell Fe3O4/Au multifunctional nanoparticles by PVP-assisted nanoemulsion process

Liu, Hongling; Hou, Peipei; Zhang, WengXing; Wu, Junhua

doi:10.1016/j.colsurfa.2009.12.023

Cited by 72 publications

(40 citation statements)

References 32 publications

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“…. The change of the spectrum indicates that the absorption of PVP on the gold shell is not on the basis of electrostatic attraction but gold atoms on the surface of nanoparticles would coordinate with N and O atoms of PVP which is consistent with previously reported results [26]. FTIR confirms the presence of a PVP coating on the nanoshells.…”

Section: Discussionsupporting

confidence: 90%

In-vitro Application of Doxorubicin Loaded Magnetoplasmonic Thermosensitive Liposomes for Laser Hyperthermia and Chemotherapy of Breast Cancer

Khosroshahi

Ghazanfari²,

Hassannejad³

et al. 2015

J Nanomed Nanotechnol

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We describe doxorubicin loaded magnetoplasmonic thermosensitive liposomes (MPTL-DOX), which are designed to combine features of magnetic drug targeting and laser hyperthermia-triggered drug release. The synthesized magnetite/gold nanoshells are stabilized using polyvinyl pyrolidone (PVP) with mean crystallite size of 15.8 ± 3.5 nm. The liposome formulation DPPC:cholesterol:DSPE-PEG2000 at 80:20:5 molar ratio shows DOX release of less than 5% at 37°C following 24 h incubation. MPTL-DOX shows encapsulation efficiencies of about 95% and 74% for DOX and magnetoplasmonic nanoshells (MPNS), respectively. The MPTL-DOX formulation displays a desired temperature sensitivity with 65% and 100% DOX release following laser irradiation and then 24 h incubation at 37°C, respectively. The rate of DOX release from liposome using this formulation is 0.09 which was obtained by heating to 43°C, and agrees well with the first kinetic model. A temperature rise between 4-12°C was achieved for MNS using 25 μg/ml and 300 μg/ml after 400 s respectively. For cytotoxicity measurement, one untreated (control) and two treatment groups are studied. The first treatment groups are: with MPNS only, with MPTL only, and laser irradiation only. The second treatment groups are: laser hyperthermia using MPTL, MPTL with magnetic field (MF), MPTL-DOX, and MPTL-DOX with MF. MPTL-DOX is targeted to breast cancer cell lines (MCF-7 cells) under a permanent magnetic field and exhibits a substantial increase in cytotoxicity and apoptotic effects. The results suggest that externally guided drug targeting can trigger drug release using an exogenous absorber in laser hyperthermia which can be used advantageously for thermo-chemotherapy of cancers.

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Section: Discussionsupporting

confidence: 90%

In-vitro Application of Doxorubicin Loaded Magnetoplasmonic Thermosensitive Liposomes for Laser Hyperthermia and Chemotherapy of Breast Cancer

Khosroshahi

Ghazanfari²,

Hassannejad³

et al. 2015

J Nanomed Nanotechnol

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“…The resulting AuFe nanocrystals show high monocrystallinity, in sharp contrast to the polycrystalline state of the similar nanoparticles obtained previously [11,12]. In our experiments, the polymer dominantly plays the role of a surfactant, whereas the functioning of reduction is taken by the much stronger reductant of 1,2-hexadecanediol [15,20].…”

Section: Introductionmentioning

confidence: 46%

“…A variety of polymers have been investigated for the formation of micelles to construct tailored nanomaterials [14][15][16][17]. The triblock copolymer, poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEO-PPO-PEO) shows biocompatibility, non-charging trait, non-toxicity, and aqueous solubility and has been used in emulsion processes as a surfactant, besides the stabilization effect and the role of a reducing agent [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Facile growth of monocrystalline gold–iron nanocrystals by polymer nanoemulsion

et al. 2011

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Monodisperse, monocrystalline AuFe opticalmagnetic multifunctional nanocrystals were prepared by the nanoemulsion method using a copolymer surfactant. The structure and properties of the monocrystalline nanocrystals were analyzed by X-ray diffraction, transmission electron microscopy (TEM, including high-resolution TEM), selected-area electron diffraction, UV-vis spectroscopy, and vibration sampling magnetometry. The characterization shows the outstanding monodispersity and high monocrystallinity of the nanocrystals, which possess both well-defined optical and magnetic properties revealing broadband absorption with the surface plasmon resonance, peaking at~600 nm, and clear soft ferromagnetic behavior at room temperature. Such long-term stable, monocrystalline AuFe nanocrystals have novel optical and magnetic properties, which may offer exciting opportunities in fundamental studies and tremendous applications.

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“…Metal oxide [17, 66 -70] , metallic, mainly Fe and Co [71 -73] , and bimetallic, such as FePt [74,75] MNPs have been proposed for this purpose. Many of these materials were coated, to provide an inert and biologically compatible outer shell made of silica [67] , gold [43,57,76] or carbon [71,73] . [36,48] .…”

Section: Biomedicalmentioning

confidence: 99%

Application of alternative energy forms in catalytic reactor engineering

Houlding

Rebrov

2012

Green Processing and Synthesis

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This review provides a general overview of recent applications of magnetic nanoparticles for controlled radiofrequency (RF) heating in catalytic synthesis, mass transfer enhancement in laminar fl ow and magnetic separation. By directly delivering RF energy to magnetic materials, issues such as long heating periods and energy losses can be minimized. The main mechanisms of RF heating are briefl y reviewed. The effect of nanoparticles size, shape and composition on the effi ciency of RF heating is discussed. RF energy has been shown to be effective in many applications, however, it is still not used in chemicals due to high equipment costs.

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Synthesis of monosized core–shell Fe3O4/Au multifunctional nanoparticles by PVP-assisted nanoemulsion process

Cited by 72 publications

References 32 publications

In-vitro Application of Doxorubicin Loaded Magnetoplasmonic Thermosensitive Liposomes for Laser Hyperthermia and Chemotherapy of Breast Cancer

In-vitro Application of Doxorubicin Loaded Magnetoplasmonic Thermosensitive Liposomes for Laser Hyperthermia and Chemotherapy of Breast Cancer

Facile growth of monocrystalline gold–iron nanocrystals by polymer nanoemulsion

Application of alternative energy forms in catalytic reactor engineering

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