Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification

Abstract

Monodispersed spherical Ag-doped bioactive glass nanoparticles (Ag-BGNs) were synthesized by a modified Stöber method combined with surface modification. The surface modification was carried out at 25, 60, and 80 °C, respectively, to investigate the influence of processing temperature on particle properties. Energy-dispersive X-ray spectroscopy (EDS) results indicated that higher temperatures facilitate the incorporation of Ag. Hydroxyapatite (HA) formation on Ag-BGNs was detected upon immersion of the particles in simulated body fluid for 7 days, which indicated that Ag-BGNs maintained high bioactivity after surface modification. The conducted antibacterial assay confirmed that Ag-BGNs had an antibacterial effect on E. coli. The above results thereby suggest that surface modification is an effective way to incorporate Ag into BGNs and that the modified BGNs can remain monodispersed as well as exhibit bioactivity and antibacterial capability for biomedical applications.

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

“…The as-synthesized BGN have shown apatite-forming ability as reported in our previous study, 44 and hydroxyapatite (HA) can form on BGN after immersion in SBF within 7 days. However, the coating of ZnO QDs on BGN inhibited the bioactivity of particles, as no significant formation of HA could be observed in ZnO-BGN upon immersion in SBF for 14 days according to the FTIR spectrum (Fig.…”

“…Alternatively, post modification of silica nanoparticles or binary BGN to introduce metallic ions has been shown to be able to avoid the aggregation of nanoparticles. 44,51 In this study, ZnO QDs were used as modification agents to introduce Zn ions. The modification was based on electrostatic interaction that could retain the structure and properties of the involved components.…”

Novel Antibacterial and Bioactive Silicate Glass Nanoparticles for Biomedical Applications

“…Effectively, these materials were able to bond not only to bone, but to soft tissue as well, avoiding fibrous encapsulation. [5,16,17] Regarding the production of silver doped bioactive nanoparticles in the system SiO 2 -CaO-P 2 O 5 -Ag 2 O through the sol-gel methodology, some interesting works have been already developed with different silver contents. In fact, the implantation of materials for prostheses and tissue regeneration is often associated with the administration of antibiotics.…”

“…In fact, the implantation of materials for prostheses and tissue regeneration is often associated with the administration of antibiotics. On the other hand, some studies have reported that silver nanoparticles could induce some cytotoxicity effects, depending on the used concentration and on the culture time, typically at higher Ag contents, [14,16,20,21] in the present work our interest was focused on the development of an alternative and simple sol-gel methodology for the synthesis of new silicate glass nanoparticles with 10 mol% of silver oxide, using the same bioglass precursors described in a previous protocol developed and optimized by our group for a ternary bioglass system. [5] Ideally, the implant should have the ability to both regenerate bone tissue and to treat the infection by delivering an antibacterial agent in a controlled and continuous manner.…”

“…[8,12,15] Silver doping of bioactive nanoparticles is an interesting strategy that has been investigated for different biomedical applications, since it combines the bioactive properties from the bioglass composition with the antibacterial capacity induced by their silver content. [5,16,17] Regarding the production of silver doped bioactive nanoparticles in the system SiO 2 -CaO-P 2 O 5 -Ag 2 O through the sol-gel methodology, some interesting works have been already developed with different silver contents. [5,14,[17][18][19] In particular, Bellantone et al [18] developed a formulation with a 3 wt(%) Ag 2 O, Delben et al [17] studied different formulations with a maximum of 5 mol% Ag, but only El-Kady et al [5] and Vulpoi et al [19] synthesized nanoparticles with 10 mol%.…”