“…The obtained NP suspension was dried in the oven at 35 °C. NP aggregation was observed by SEM after being dried …”
Section: Methodsmentioning
confidence: 99%
“…NP aggregation was observed by SEM after being dried. 47 PtOEPK NPs Sol−Gel. A blank sol−gel matrix was prepared according to the previous report, but DAOTA was removed from the 3-(glycidoxy)propyltrimethoxysilane (GPTMS) gel component.…”
As part of moving our optical pH and dissolved oxygen (DO) optical chemosensors toward industrial applications, we decided to explore a many-sensors-in-one principle. It was tested if physical segregation of the optical sensor components in a single sensor polymer could remove cross-talk and quenching. It was found that a design concept with an oxygen-responsive dye in polymer nanoparticles and a pH-responsive dye in an organically modified siloxane polymer resulted in a robust pH/O 2 dual optical sensor. Individually, the O 2 -sensitive nanoparticles, a known component for optical DO sensing, and the pH sensor are operational. Thus, it was decided to test if nanoparticles enclosed within the pH-sensitive responsive sol−gel (i) could work together if segregated and (ii) could operate with a single intensity signal that is without a reference signal; developments within industrial optical sensor technology indicate that this should be feasible. The prototype optode produced in this work was shown to have a negligible drift over 60 h, bulk diffusion-limited DO response, and independent response to pH and O 2 . On the individual optode, pH calibration was found to show the expected sigmoidal shape and pK a , while the complexity of the calibration function for the DO signal was significant. While the engineering of the sensor device, optics, and hardware are not robust enough to attempt generic sensor calibration, it was decided to demonstrate the design concept in simple fermentation experiments. We conclude that the dual sensor design with the physical segregation of components is viable.
“…The obtained NP suspension was dried in the oven at 35 °C. NP aggregation was observed by SEM after being dried …”
Section: Methodsmentioning
confidence: 99%
“…NP aggregation was observed by SEM after being dried. 47 PtOEPK NPs Sol−Gel. A blank sol−gel matrix was prepared according to the previous report, but DAOTA was removed from the 3-(glycidoxy)propyltrimethoxysilane (GPTMS) gel component.…”
As part of moving our optical pH and dissolved oxygen (DO) optical chemosensors toward industrial applications, we decided to explore a many-sensors-in-one principle. It was tested if physical segregation of the optical sensor components in a single sensor polymer could remove cross-talk and quenching. It was found that a design concept with an oxygen-responsive dye in polymer nanoparticles and a pH-responsive dye in an organically modified siloxane polymer resulted in a robust pH/O 2 dual optical sensor. Individually, the O 2 -sensitive nanoparticles, a known component for optical DO sensing, and the pH sensor are operational. Thus, it was decided to test if nanoparticles enclosed within the pH-sensitive responsive sol−gel (i) could work together if segregated and (ii) could operate with a single intensity signal that is without a reference signal; developments within industrial optical sensor technology indicate that this should be feasible. The prototype optode produced in this work was shown to have a negligible drift over 60 h, bulk diffusion-limited DO response, and independent response to pH and O 2 . On the individual optode, pH calibration was found to show the expected sigmoidal shape and pK a , while the complexity of the calibration function for the DO signal was significant. While the engineering of the sensor device, optics, and hardware are not robust enough to attempt generic sensor calibration, it was decided to demonstrate the design concept in simple fermentation experiments. We conclude that the dual sensor design with the physical segregation of components is viable.
“…The formation of solid particles may take place during or after the polymerization process (Figure 1). Different polymeric nanoparticles were prepared using this method such as poly(methyl methacrylate) (PMMA) [11], and poly[styrene/(dimethylamino)ethyl methacrylate] nanoparticles [12]. Recently, curcuminoid-loaded PMMA nanoparticles were prepared using emulsion polymerization in the presence of AIBN as initiator, and SDS as a surfactant.…”
Nanoparticles have become a major player in pharmaceutical research and drug design. By encapsulation of a drug into a nanostructure, its stability can be preserved, its solubility can be enhanced and its pharmacokinetic profile can be boosted as well. In addition, using a drug carrier can open the doors to different drug targeting strategies that improve the specificity of the drug and reduce toxicity and side effects accordingly. Many nanoparticles preparation methods exist, the most abundant are emulsion based, precipitation based and polymerization based methods. However, these particle types and delivery methods do not provide optimal delivery. Durg targeting strategies using passive approach must also be taken into consideration. In this chapter, the most abundant preparation methods will be discussed and examples for different kinds of nanoparticles will be given. Furthermore, the widely studied targeting strategies that are of paramount importance to drug delivery will be explained.
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