Synthesis of molecularly imprinted polymer as a sorbent for solid phase extraction of citalopram from human serum and urine

Abdouss, Majid; Azodi‐Deilami, Saman; Asadi, Ehsan; Shariatinia‬, Zahra

doi:10.1007/s10856-012-4623-5

Cited by 42 publications

(16 citation statements)

References 37 publications

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“…Moreover providing an approach in terms of bypassing the BBB and targeting the receptor site to achieve desired OLZ concentration at its site of action appears beneficial. For a study of extraction of solid phase by MIPs, it should be stated that a few types of extraction methods are routinely used in analytical toxicology, such as liquid-liquid extraction (LLE) [35], liquid-liquid micro-extraction (LLME) [36][37], solid phase extraction (SPE) [38], solid-phase micro-extraction (SPME) [39], and molecularly imprinted solid phase extraction (MISPE) [40][41][42]. Although SPE is the most convenient method for extraction due to its simplicity in terms of, labor intensive and solvent consuming, MISPE is currently a growing field in clean up techniques for the analysis of biological samples.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

et al. 2015

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Nowadays, polymeric nanoparticles have drawn more attention as drug carrier by investigators.In this study, we synthesized high selective imprinted nanoparticle polymer using olanzapine as template. The aim of this study was preparing efficient imprinted polymer nanoparticles from olanzapine as the template for the controlled release of olanzapine as a therapeutic drug for central nervous systems (CNS) disease at different pH values and the solid-phase extraction (SPE) as the sample clean-up technique combined with high-performance liquid chromatography (HPLC). The morphology of the nanoparticles was determined using scanning electron microscopy (SEM) images. Drug release, binding properties and dynamic light scattering (DLS) of the molecularly imprinted polymers (MIPs) were studied in this investigation. The adsorption isotherm was fitted with Langmuir and Freundlich models. The performance of the MIPs for the controlled release of olanzapine was assessed in two different media (SDS 1% and PBS). Results revealed that the MIPs have potential application in controlled drug release. Moreover, cytotoxicity of the MIP nanoparticles was measured on NIH/ 3 T3 cell line using MTT method.Furthermore, the MIPs were applied to extraction of olanzapine from human blood plasma samples. The limit of detection (LOD) and limit of quantification (LOQ) were evaluated and were 0.18 µg L -1 and 0.39 µg L -1 , respectively. These results collectively illustrate that MIP nanoparticles can be employed as an efficient technique for the extraction of the olanzapine from human plasma.

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Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

et al. 2015

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“…In the pre-polymerization mixture, the functional monomers are self-assembled around the template molecule mainly through noncovalent interactions. Hence, matching functionality of the template and monomer is required to maximize complex formation [36]. The UV-Vis spectra were recorded in discrete solutions of GUA, pyrrole, and their mixture prepared in EtOH.…”

Section: Preparation Of Guaifenesin Imprinted Polymermentioning

confidence: 99%

A new molecularly imprinted polymer for selective extraction and pre‐concentration of guaifenesin in different samples: Adsorption studies and kinetic modeling

Iranmanesh

Jahani²,

Nezhadali

et al. 2020

J of Separation Science

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This paper describes the synthesis of a molecularly imprinted polymer by chemical oxidation of pyrrole as the functional monomer, and at the presence of guaifenesin as the template. The prepared polymer was used as adsorbent in molecularly imprinted solid‐phase extraction followed by spectrophotometric determination. Different parameters in the solid‐phase extraction including sample pH, adsorbent weight, washing solution, and elution solvent were studied to determine optimum conditions for isolation and enrichment of guaifenesin. The results showed guaifenesin was quantitatively adsorbed on the molecularly imprinted polymer at pH 6.0 and completely eluted with an ethanol–water solution (50% v/v). An enrichment factor of four with satisfactory recoveries (87.0–95.0%) was obtained. The solid‐phase extraction columns could be used for up to six consecutive elution‐loading cycles without significant decreases in the analyte recoveries. The method had a dynamic range of 3.0 × 10−6–1.5 × 10−4 mol/L with a limit of detection and limit of quantification of 1.4×10−6 and 4.5×10−6 mol/L, respectively. The proposed procedure was used for the extraction and determination of guaifenesin in different pharmaceutical formulations, with satisfying results being achieved.

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“…(5) and (6) and pseudo-second-order rate eqs. (7) and (8), respectively. 47 q t 5q e 2q e e 2k1t (5) ln q e 2q t ð Þ5ln q e 2k 1 t (6) q t 5 k 2 q 2 e t 11k 2 q e t (7)…”

Section: Adsorption Kineticsmentioning

confidence: 99%

“…A few types of extraction method are used routinely in analytical toxicology such as liquid–liquid extraction (LLE), liquid–liquid micro‐extraction (LLE), solid phase extraction (SPE), solid‐phase micro‐extraction (SPME), and molecularly imprinted solid phase extraction (MISPE) . Currently, the most convenient method for extraction of drugs in biological fluids is SPE due to its simplicity and versatility which leaves LLE, which is labor intensive and solvent consuming, far behind in analytical methodologies.…”

Section: Introductionmentioning

confidence: 99%

Magnetic molecularly imprinted polymer nanoparticles coupled with high performance liquid chromatography for solid‐phase extraction of carvedilol in serum samples

Azodi‐Deilami

Abdouss

Asadi

et al. 2014

J of Applied Polymer Sci

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Herein, we report a magnetic molecularly imprinted polymers (m-MIPs) using Fe 3 O 4 as a magnetic component, carvedilol as a template molecule for the solid-phase extraction (MISPE) as the sample clean-up technique combined with high-performance liquid chromatography (HPLC) and for the controlled release of carvedilol at different pH values of 1.0 (simulated gastric fluid), 6.8 (simulated intestinal fluid), and 7.4 (simulated biological fluid). The adsorption kinetics was modeled with the pseudo-first-order and pseudosecond-order kinetics, and the adsorption isotherms were fitted with Langmuir and Freundlich models. The performance of the m-MIPs for the controlled release of carvedilol was assessed and results indicated that the magnetic MIPs also have potential applications in controlled drug release. Furthermore, the m-MIPs were applied to the extraction of carvedilol from human blood plasma samples. Carvedilol can be quantified by this method in the 2-350 lg L 21 concentration range. The limit of detection and limit of quantification in plasma samples are 0.13 and 0.45 lg L 21. The results from HPLC showed good precision (3.5% for 50.0 lg L 21 ) and recoveries (between 85 and 93) using m-MIP from human plasma samples.

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Synthesis of molecularly imprinted polymer as a sorbent for solid phase extraction of citalopram from human serum and urine

Cited by 42 publications

References 37 publications

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

A new molecularly imprinted polymer for selective extraction and pre‐concentration of guaifenesin in different samples: Adsorption studies and kinetic modeling

Magnetic molecularly imprinted polymer nanoparticles coupled with high performance liquid chromatography for solid‐phase extraction of carvedilol in serum samples

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