Synthesis of molecular imprinting polymers for extraction of gallic acid from urine

Abstract

The molecularly imprinted polymers for gallic acid were synthesized by precipitation polymerization. During the process of synthesis a non-covalent approach was used for the interaction of template and monomer. In the polymerization process, gallic acid was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker and 2,2′-azobisisobutyronitrile as an initiator and acetonitrile as a solvent. The synthesized imprinted and non-imprinted polymer particles were characterized by using Fourier-transform infrared spectroscopy and scanning electron microscopy. The rebinding efficiency of synthesized polymer particles was evaluated by batch binding assay. The highly selective imprinted polymer for gallic acid was MIPI1 with a composition (molar ratio) of 1:4:20, template: monomer: cross-linker, respectively. The MIPI1 showed highest binding efficiency (79.50%) as compared to other imprinted and non-imprinted polymers. The highly selective imprinted polymers have successfully extracted about 80% of gallic acid from spiked urine sample.

Molecularly imprinted polymers—A closer look at the control polymer used in determining the imprinting effect: A mini review

“…It is synthesized following the steps outlined in Figure 1 Likewise, selectivity is defined by selectivity factor (α), selectivity coefficient (k), or relative selectivity coefficient (k 0 ) given by Equations (5-8). [29][30][31][32] Values greater than one for selectivity, indicate that the imprinted polymer is able to differentiate closely related compounds and therefore an imprinting effect has occurred making it selective to the analyte. 33 Relative selectivity indicates the magnitude of selectivity of the MIP in relation to the NIP, where values greater than one imply that the MIP is more selective to the analyte.…”

“…Likewise, selectivity is defined by selectivity factor ( α ), selectivity coefficient ( k ), or relative selectivity coefficient ( k ′) given by Equations ) 29‐32 . Values greater than one for selectivity, indicate that the imprinted polymer is able to differentiate closely related compounds and therefore an imprinting effect has occurred making it selective to the analyte 33 .…”

Synthesis of molecularly imprinted polymer for removal of Congo red

“…9a and b, present the surface morphology of CR1-MIP particles The micrographs clearly revealed the surface with a porous texture having very tiny and homogeneous spherical particles that have been developed with a narrow size distribution in the range of micrometers ~ 0.07 µm. Uniformity in size and shape was owed to non-covalent precipitation polymerization method [41][42][43][44]. The uniformly sized MIP have advantages of possessing 'large surface area, monodispersed, colloidal stability' as compared to the irregularly shaped MIP particles.…”

Characterization of Imprinted Polymer of Diazepam With Methacrylic Acid and Hydroxyethyl Methacrylate Monomer in Chloroform for Selective Adsorption of Diazepam

“…29 Morfologi dari bentuk polimer sangat dipengaruhi oleh metode polimerisasi. 30 Proses penumbukkan dalam polimerisasi ruah dapat menghasilkan bentuk dan ukuran yang tidak beraturan. Selain itu juga menghasilkan distribusi yang cenderung heterogen dalam polimer.…”