Synthesis of Modified Hydroxyapatite (HAP) Substituted With Fe Ion for DDS Application

Nakahira, A.; Nakamura, Shinya; Horimoto, M.

doi:10.1109/tmag.2007.894358

Cited by 24 publications

(12 citation statements)

References 11 publications

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“…Incorporation of Fe into HAp crystal structure to impart magnetic properties to the material 18 and the resulting promotion of bone remodeling and tissue regeneration have also been reported 19 . Further, Fe-doped HAp has also been exploited for its superparamagnetic nature 20 as well as to deliver drugs 21 and boost the osteoblastic activity 22 , thus positively affecting bone regeneration. Cobalt-incorporated HAp has been shown to favor osteogenesis in vivo 23 , while also demonstrating an antibacterial activity 24 .…”

Section: Introductionmentioning

confidence: 99%

One ion to rule them all: the combined antibacterial, osteoinductive and anticancer properties of selenite-incorporated hydroxyapatite

Uskoković

Iyer

2017

J. Mater. Chem. B

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Although hydroxyapatite (HAp) has been doped with dozens of different ions, the quest for an ion imparting a combination of properties conducive to bone healing is still ongoing. Because of its protean potency and the similarity in size and shape to the phosphate tetrahedron, selenite ion presents a natural ionic substitute in HAp. The incorporation of selenite into synthetic HAp using two different methods – co-precipitation and ion-exchange sorption - was studied for its effect on crystal properties and on a triad of biological responses: antibacterial, anticancer and osteoinductive. Co-precipitation yielded HAp with higher selenite contents than sorption and the stoichiometry of HAp richest in selenite was represented as Ca9.75(PO4)5.75(SeO3)0.25(OH)1.75. Crystallinity of HAp decreased in direct proportion with the amount of selenite incorporated. Because of their lower selenite content, HAp powders prepared by ion-exchange exhibited a consistently higher crystallinity compared to the co-precipitated ones. Annealing partially recovered the crystallinity, yet the difference in crystallinity between powders prepared by co-precipitation and by ion-exchange remained, suggesting that the amorphization is mainly due to structural incorporation of selenite, not its effect on the crystal growth kinetics. The addition of selenite changed the morphology of HAp nanoparticles from acicular to rounded and affected the crystal lattice parameters in different ways depending on whether the powders were annealed or not. As for the annealed powders, the incorporation of selenite contracted the lattice in both a and c crystallographic directions. In the agar diffusion assay, the effectiveness of HAp was more dependent on the presence or absence of selenite in it than on its concentration and was highest against E. coli and S. aureus, moderately high against S. enteritidis and ineffective against P. aeruginosa. In liquid inoculation tests, on the other hand, the antibacterial activity of HAp was directly proportional to the amount of selenite contained in it. The viability of K7M2 osteosarcoma cells decreased in direct proportion with the amount of selenite in HAp and was significantly different from the untreated control and from pure HAp at contents equal to or higher than 1.9 wt.%. In contrast, no reduction was observed in the viability of primary fibroblasts treated with HAp incorporating different amounts of selenite ions, suggesting their potentially selective anticancer activity: lethal for the cancer cells and harmless for the healthy cells. Finally, mRNA expression of bone gamma-carboxyglutamate protein (BGLAP3) was higher in differentiated MC3T3-E1 osteoblastic cells treated with selenite-incorporated HAp particles than in cells treated with pure HAp. The osteoinductive effect was due to an overall higher metabolic activity of cells treated with the particles and not due to increased proliferation. In such a way, a triad of antibacterial, osteoinductive and anticancer activities was attributed to selenite-incorporated ...

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Section: Introductionmentioning

confidence: 99%

One ion to rule them all: the combined antibacterial, osteoinductive and anticancer properties of selenite-incorporated hydroxyapatite

Uskoković

Iyer

2017

J. Mater. Chem. B

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“…For Fe 2+ doped HAp, different results were obtained. Nakahira et al [43] reported that Fe 2+ doped HAp synthesized using ion exchange method was paramagnetic, while Wu et al [44] produced Fe 2+ doped HAp using coprecipitation method and found it was super paramagnetic. In the case of Fe 3+ substituted HAp, it was found to be paramagnetic [45].…”

Section: Juniper Online Journal Materials Sciencementioning

confidence: 99%

Fabrication and Applications of Metal-Ion-Doped Hydroxyapatite Nanoparticles

Li¹

2017

JOJMS

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Calcium hydroxyapatite (HAp) is the main inorganic component of natural bones. In this review, the crystal structure and fabrication methods of HAp were first introduced; then the synthesis and applications of metal-ion-doped HAp nanoparticles were mainly reviewed. HAp was usually synthesized through solid state reaction and wet chemical precipitation, of which the properties depended on the fabrication method. Due to its crystal structure, HAp can tolerate ion-exchange with a high amount of other ions without significantly affecting its lattice structure. Hence ion-exchange reaction of HAp has been used to remove heavy metal ions such as Pb 2+ or Cd 2+ in waste water or soils, and immobilize radioactive waste. The adsorption capacity depended on the crystallinity and specific surface area of HAp. Meanwhile other metal ions besides Ca can be introduced into HAp through ion exchange or co precipitation method to form metal ion doped HAp. Due to the presence of these metal ions, the properties of HAp were either enhanced or new properties were introduced. The electrical conductivity and catalysis effect of HAp were increased due to ion substitution; the metal ion doped HAp demonstrated potential for better performance in tissue engineering, can be paramagnetic or used as fluorescence probes. The applications of HAp were thus broadened.

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“…The syntheses of HAP substituted with other metals have been eagerly attempted by various synthetic processes, such as hydrothermal treatments, ion-exchange treatments, and normal heat-treatments at high temperature in order to enhance the ion exchange ability and bioactivity of HAP [9][10][11][12][13][14][15]. For example, Fe substituted HAP i.e.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of Calcium-Deficient Hydroxyapatite with SiO<sub>2</sub>

Nakahira¹,

Nakata²,

Numako³

et al. 2011

MSA

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Synthesis of Modified Hydroxyapatite (HAP) Substituted With Fe Ion for DDS Application

Cited by 24 publications

References 11 publications

One ion to rule them all: the combined antibacterial, osteoinductive and anticancer properties of selenite-incorporated hydroxyapatite

One ion to rule them all: the combined antibacterial, osteoinductive and anticancer properties of selenite-incorporated hydroxyapatite

Fabrication and Applications of Metal-Ion-Doped Hydroxyapatite Nanoparticles

Synthesis and Evaluation of Calcium-Deficient Hydroxyapatite with SiO<sub>2</sub>

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Synthesis of Modified Hydroxyapatite (HAP) Substituted With Fe Ion for DDS Application

Cited by 24 publications

References 11 publications

One ion to rule them all: the combined antibacterial, osteoinductive and anticancer properties of selenite-incorporated hydroxyapatite

One ion to rule them all: the combined antibacterial, osteoinductive and anticancer properties of selenite-incorporated hydroxyapatite

Fabrication and Applications of Metal-Ion-Doped Hydroxyapatite Nanoparticles

Synthesis and Evaluation of Calcium-Deficient Hydroxyapatite with SiO&lt;sub&gt;2&lt;/sub&gt;

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Synthesis and Evaluation of Calcium-Deficient Hydroxyapatite with SiO<sub>2</sub>