Synthesis of Methyl 5(6)‐(4‐Aminophenoxy)‐ and 5(6)‐(2‐Aminophenoxy)‐2‐benzimidazolyl Carbamates and Their Biological Properties.

Abstract

Synthesis of Methyl 5(6)-(4-Aminophenoxy)-and 5(6)-(2-Aminophenoxy)-2-benzimidazolyl Carbamates and Their BiologicalProperties. -A novel procedure for the synthesis of carbamate (VIII) in high yields is developed. An analogous procedure is applied to the preparation of the carbamate (IX) from 2-nitrochlorobenzene. The data concerning helminthicidal activity, embryotoxicity and overall toxicity are reported. -(PILYUGIN, V. S.; MIKHAILYUK, A. N.; KOSAREVA, V. M.; CHIKISHEVA, G. E.; KISELEVA, G. V.; KUZNETSOVA, S. L.; VOROBYEVA, T. P.; KLIMAKOVA, E. V.; Russ.

4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation

“…The appearance of C]O stretch in the range of 1630e1600 cm À1 indicated the formation of tertiary amides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) by the reaction of acid chlorides with the 4-(1H-benzoimidazol-2yl)-benzenesulfonic acid. The primary amino group in compound 1 is depicted by the presence of NH asymmetric stretch at 3481.81 cm À1 .…”

“…Furthermore, the topological parameter, Balaban index (J) followed by the electronic parameter, LUMO and topological parameter, valence second order molecular connectivity index ( 2 c v ) is describing the antimicrobial activity of 4-[1-(substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”