Synthesis of Metal Nanoparticles Inside Living Human Cells Based on the Intracellular Formation Process

El‐Said, Waleed A.; Cho, Hyeon-Yeol; Yea, Cheol-Heon; Choi, Jeong‐Woo

doi:10.1002/adma.201303699

Cited by 61 publications

(50 citation statements)

References 43 publications

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“…The biosynthesis NPs is observed even human cells (Anshup et al, 2005;El-Said et al, 2014), and generally in biochemical systems derived from living things, that is, systems that exhibit reducing ability as example fresh or dried extracts obtained from plant organisms (Mittal et al, 2013;Kumar et al, 2013;Huang et al, 2015), honey (Venu et al, 2011), wine (Mittal et al, 2014), or to the material obtained from cell lysis (El-Said et al, 2014). The NPs obtained can form oxides (Haverkamp and Marshall, 2008) or complex hydrated (Petit et al, 2015), but what usually happens is the NPs acquire an organic coating adsorbed on the surface of the NPs, which increases its stability and decreases aggregation (Iravani, 2011); i.e., biological agents develop a double function as reducing agents and as coating.…”

Section: Nanoparticles Biomanufacturingmentioning

confidence: 99%

“…La biosíntesis de NPs se observa incluso en células humanas (Anshup et al, 2005;El-Said et al, 2014), y en general en los sistemas bioquímicos derivados de seres vivos, es decir, sistemas que muestren capacidad reductora como por ejemplo los extractos frescos o secos obtenidos de organismos vegetales (Mittal et al 2013;Kumar et al 2013;Huang et al, 2015), la miel (Venu et al, 2011), el vino (Mittal et al, 2014), o hasta el material obtenido de la lisis celular (El-Said et al, 2014). Las NPs obtenidas pueden formar óxidos (Haverkamp y Marshall, 2008) o complejos hidratados (Petit et al, 2015), aunque lo que normalmente It seems then that the synthesis of NPs would be the first defensive responses of plants to stress induced by excess metal ions.…”

Section: Nanoparticles Biomanufacturingunclassified

“…None reported any limitation as to the transformation of ions NPs to be performed by some kind of specific compound (El-Said et at., 2014), while some authors point out specific metabolites as responsible for biotransformation (Shukla et al, 2014;Huang et al, 2015), but without providing elements to totally exclude ocurre es que las NPs adquieran un recubrimiento orgánico, adsorbido en la superficie de las NPs, que aumenta su estabilidad ya que disminuye la agregación (Iravani, 2011); es decir, los agentes biológicos desarrollan una doble función: como agentes reductores y como recubrimiento.…”

Section: Nanoparticles Biomanufacturingunclassified

“…No se ha reportado ninguna limitante en cuanto a que la transformación de iones a NPs deba realizarse por medio de algún tipo de compuesto específico (El-Said et al, 2014), aunque algunos autores señalan metabolitos específicos como los responsables de la biotransformación (Shukla et al, 2014;Huang et al, 2015), pero sin aportar elementos que permitan excluir totalmente la acción de otras biomoléculas. Si lo que se requiere es la presencia de unos cuantos metabolitos reductores diferentes en gran cantidad se usarían organismos transgénicos o sus extractos vegetales (Hong-Bo et al, 2010), o bien hiperacumuladores con innata capacidad de acumulación del elemento que se utilizará para la biosíntesis de las NPs (Iravani, 2011).…”

Section: Nanoparticles Biomanufacturingunclassified

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Biofabricación de nanopartículas de metales usando células vegetales o extractos de plantas

Morales-Díaz

Juárez‐Maldonado²,

Morelos-Moreno

et al. 2017

Remexca

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ResumenSe presenta una revisión acerca de la biofabricación de nanopartículas (NPs) de metales usando extractos vegetales, cultivos celulares de órganos o bien plantas vivas. Se describen los dos métodos de biofabricación verde de nanopartículas: el proceso bioquímico con extractos y el proceso biológico que involucra células vivas. Se discute el mecanismo redox de biofabricación de NPs, haciendo énfasis en aquellos puntos que requieren mayor dilucidación con el propósito de estandarizar los procesos para adaptarlos a un sistema industrial de producción. Se describe igualmente lo que se conoce acerca del destino de las NPs biofabricadas en células vivas, remarcando el proceso de movilización extra-e intracelular así como entre diferentes tejidos y órganos de la planta. Se discuten por último los factores que regulan la tasa de biofabricación de nanopartículas en las células y tejidos vivos, dirigiendo la atención hacia aquello que se necesita dominar para obtener biofábricas para la producción de NPs en donde la variabilidad de tamaño, forma y reactividad se ajusten a estándares industriales.Palabras clave: balance redox, bioproducción, bioreducción de metales, síntesis química verde. AbstractA review is presented on the biomanufacturing of nanoparticles (NPs) of metals using plant extracts, cell organ cultures or live plants. The two methods of manufacturing green nanoparticles are described: the biochemical process extracts and biological process involving living cells. The redox mechanism biomanufacturing of NPs is discussed, emphasizing those points that require further clarification in order to standardize processes to adapt to an industrial production system. It also describes what is known about the fate of NPs biomanufacturing in living cells, highlighting the process of extra-and intracellular as well as between different tissues and organs of the plant mobilization. Finally the factors discussed that regulate the rate of biomanufacturing of nanoparticles in living cells and tissues, directing attention to what you need to master to obtain bio-factories for the production of NPs where the variability in size, shape and reactivity fit to industry standards.

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Section: Nanoparticles Biomanufacturingmentioning

confidence: 99%

Section: Nanoparticles Biomanufacturingunclassified

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Biofabricación de nanopartículas de metales usando células vegetales o extractos de plantas

Morales-Díaz

Juárez‐Maldonado²,

Morelos-Moreno

et al. 2017

Remexca

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“…The green synthesis of MNPs may be performed using prokaryotic [ 23 ] or eukaryotic [ 4 ] organisms (including microorganisms, plants, and animals) or parts thereof, and can occur through intracellular [ 24 ] or extracellular [ 25 ] pathways. The biological components (primary and secondary metabolites) act as agents to promote the reduction of a target metal ion resulting in the formation of MNPs ( Fig.…”

Section: Green Synthesis Of Mnps: General Considerationsmentioning

confidence: 99%

Green Synthesis of Metal Nanoparticles by Plants: Current Trends and Challenges

Silva

Reis

Bonatto

2015

Green Processes for Nanotechnology

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Metal nanoparticles (MNPs) have been widely used in a range of recent scientifi c and technological applications. They can be produced by conventional chemical synthesis or green synthesis methods. Green synthesis consists of a myriad of promising approaches for the production of MNPs with desired properties. Plants represent the most explored group of living organisms for the green synthesis of MNPs, and to date, hundreds of species have been used. However, several factors that should be taken into account when performing green synthesis of MNPs remain underestimated or unexplored. This chapter does not focus on any specifi c plant species or experimental conditions leading to the synthesis of MNPs since there are numerous recent publications reviewing the literature in this outstanding fi eld. The present chapter instead focuses on the trends and challenges in MNPs synthesis using plants which include reproducibility, scale-up, predictability, and development of strategies for effective management of governance, regulatory, and

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Intracellular Liquid‐Liquid Phase Separation Induces Tunable Anisotropic Nanocrystal Growth for Multidimensional Analysis

Liu

Wang

et al. 2023

Adv Funct Materials

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Spatially directed biomineralization of nanocrystals for specific optical purposes in biological systems and elucidation of the mechanism of biomineralized nanocrystals remains a fascinating but extremely challenging task. Herein, the biomineralization of tunable gold nanocrystals with in situ protein coronas by intracellular liquid‐liquid phase separation (LLPS) for in situ molecule surface‐enhanced Raman spectrum (SERS) analysis and tumor fluorescence identification. The anisotropic nanocrystals are realized by regulating LLPS, in which the nucleation of nanocrystals is at the protein secondary structural site (β‐Corner) of the droplet, the different adsorption energies of crystal surfaces further promote the directional growth of nanocrystals. Interestingly, gold nanocrystals with ultra‐narrow fluorescence emission at half‐peak width and ultra‐long Stokes shift and can obtain in situ molecular fingerprint information of protein corona to achieve by SERS. Of note are the anisotropic nanocrystals to differentiate clinical patient tumor tissue samples. Therefore, this study reveals the mechanism of intracellular tunable nanocrystal biomineralization and provides the basis for its biomedical application.

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Synthesis of Metal Nanoparticles Inside Living Human Cells Based on the Intracellular Formation Process

Cited by 61 publications

References 43 publications

Biofabricación de nanopartículas de metales usando células vegetales o extractos de plantas

Biofabricación de nanopartículas de metales usando células vegetales o extractos de plantas

Green Synthesis of Metal Nanoparticles by Plants: Current Trends and Challenges

Intracellular Liquid‐Liquid Phase Separation Induces Tunable Anisotropic Nanocrystal Growth for Multidimensional Analysis

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