Synthesis of mesoporous SiO2–ZnO nanocapsules: encapsulation of small biomolecules for drugs and “SiOZO-plex” for gene delivery

Kumar, Vijay Bhooshan; Annamanedi, Madhavi; Prashad, Muvva Durga; Arunasree, Kalle M.; Mastai, Yitzhak; Gedanken, Aharon; Paik, Pradip

doi:10.1007/s11051-013-1904-y

Cited by 24 publications

(10 citation statements)

References 63 publications

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“…In this sense, core‐shell structures—where polymer protects the magnetic core—can enhance both the chemical stability and biocompatibility of the MNPs. In addition, its surface may be modified for obtaining specific functionalities . These magnetic colloidal particles were prepared by seeded emulsion copolymerization of styrene (St) monomer with divinylbenzene (DVB) crosslinker, in the presence of KPS as hydrophilic initiator and well‐controlled oil in water magnetic emulsion as a seed.…”

Section: Methodsmentioning

confidence: 99%

Investigation of optical, film formation, and magnetic properties of PS latex/SP‐MNPs composites

et al. 2018

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In this work, the optical, film formation, morphological and the magnetic properties of a novel type of nanocomposite system, composed of polystyrene (PS) latex and core‐shell superparamagnetic nanoparticles (SP‐MNPs), is presented. The film formation and optical properties were examined by UV‐vis technique, morphological changes by scanning electron microscopy and magnetic properties studied using vibrating sample magnetometer (VSM) as a function of SP‐MNPs content. A series of mixtures were prepared by mixing of PS latex dispersion with different amount of SP‐MNPs in the range of (0–100 wt%). PS/SP‐MNPs films were then prepared from these mixtures on glass substrates using drop casting method. After drying, film was separately annealed at elevated temperatures between 100°C and 250°C. In order to monitor film formation process, transmittance of these composites was measured after each annealing step as a function of SP‐MNPs content. It was found that below a critical SP‐MNPs content, PS percolates into the SP‐MNPs hard phase and forms an interconnected network upon annealing. However, above this critical value, PS latexes were no longer film forming at all temperatures. Besides, composite films showed superparamagnetic behaviors. The saturation magnetization (Ms) first increased and reached to 0.014 emu/cm3 at 50 wt% SP‐MNPs, then decreased to 0.010 emu/cm3 with increasing SP‐MNPs content. The maximum value of Ms was approximately 0.020 emu/cm3 and was obtained for the 85 wt% SP‐MNPs content film. These results indicated that the optical, film formation and magnetic properties of PS/SP‐MNPs composite films can be readily tuned by varying SP‐MNPs content. POLYM. COMPOS., 40:1018–1033, 2019. © 2018 Society of Plastics Engineers

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Section: Methodsmentioning

confidence: 99%

Investigation of optical, film formation, and magnetic properties of PS latex/SP‐MNPs composites

et al. 2018

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“…Different organic and inorganic substances can be used as materials for nanostructures’ shells and cores to achieve different effects and physical properties [ 95 ]. The differences in the materials used for core–shell nanostructures and, subsequently, their physical characteristics can make use of a new class of nanomaterials with a wide range of applications (e.g., bio-nanotechnology, magnetic devices, nano optics and nanomedicine) [ 96 , 97 , 98 , 99 ]. Core–shell nanostructures can be produced by a two-step sequential reaction in which, first, the core is formed and, then, the shell is made up [ 100 ].…”

Section: Nanomaterials Ultrasonic Synthesismentioning

confidence: 99%

Recent Advances in Inorganic Nanomaterials Synthesis Using Sonochemistry: A Comprehensive Review on Iron Oxide, Gold and Iron Oxide Coated Gold Nanoparticles

2021

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Sonochemistry uses ultrasound to improve or modify chemical reactions. Sonochemistry occurs when the ultrasound causes chemical effects on the reaction system, such as the formation of free radicals, that intensify the reaction. Many studies have investigated the synthesis of nanomaterials by the sonochemical method, but there is still very limited information on the detailed characterization of these physicochemical and morphological nanoparticles. In this comprehensive review, recent advances in the sonochemical synthesis of nanomaterials based on iron oxide nanoparticles (Fe3O4NP), gold nanoparticles (AuNP) and iron oxide-coated gold nanoparticles (Fe3O4@Au NP) are discussed. These materials are the most studied materials for various applications, such as medical and commercial uses. This review will: (1) address the simple processing and observations on the principles of sonochemistry as a starting point for understanding the fundamental mechanisms, (2) summarize and review the most relevant publications and (3) describe the typical shape of the products provided in sonochemistry. All in all, this review’s main outcome will provide a comprehensive overview of the available literature knowledge that promotes and encourages future sonochemical work.

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“…ZnO is also reported to possess anti-cancer activity due to reactive oxygen species (ROS) generation [11]. So, combined potential of SiO 2 @ZnO for photoluminescence and ultrasound imaging is an edge that may be used in the field of theranostics [12][13][14].Various combinations of SiO 2 and ZnO have been explored for biomedical applications. Han et al [15] prepared ZnO/silica core-shell composites and hollow silica particles and films, indicating their potential use in drug delivery.…”

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confidence: 99%

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confidence: 99%

Facile synthesis of multifunctional m‐SiO ₂ @ZnO nanocomposite employing biocompatible polymers for potential theranostic applications

Hassan

Anis

Khurshid

et al. 2020

Micro & Nano Letters

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Mesoporous materials are a class of porous nanomaterials with pore size of 2 to 50 nm [1]. Specifically, mesoporous silica (m-SiO 2) is a popular research subject in biomedical applications due to its good biocompatibility, high drug-loading capacity, large pore density, size tunability, and ability for facile surface modification [2]. A variant of research on m-SiO 2 is its combinations with some functional nanoparticles (NPs), for example, iron oxide, ZnO, etc. ZnO/SiO 2 nanocomposites have been studied for different applications such as dye degradation [3], in oil recovery [4], in photocatalysis [5], and in optical and optoelectronic applications [6, 7]. Such structures have potential for theranostic applications as well. Unlike conventional imaging and therapy techniques, they are capable of simultaneously carrying therapeutic drugs along with diagnostic or imaging agents which can be helpful in magnetic resonance imaging (MRI) or photoluminescence imaging. They may also act as safe carriers for drugs which otherwise exhibit toxicity or instability if used on their own [8]. Moreover, their surfaces can be functionalized to achieve targeted drug delivery to tumours [9]. Efforts to successfully bring these materials to mainstream clinical medicine are still underway [8]. ZnO has a potential use in photoluminescence imaging due to its luminescence under UV rays [10]. ZnO is also reported to possess anti-cancer activity due to reactive oxygen species (ROS) generation [11]. So, combined potential of SiO 2 @ZnO for photoluminescence and ultrasound imaging is an edge that may be used in the field of theranostics [12-14]. Various combinations of SiO 2 and ZnO have been explored for biomedical applications. Han et al. [15] prepared ZnO/silica core-shell composites and hollow silica particles and films, indicating their potential use in drug delivery. Generalov et al. studied the radiosensitizing effect of ZnO/silica nanocomposites [16]. They found that ZnO-silica core-shell NPs improve results of radiation therapy employed for certain cancer cell lines. Photoluminescence properties of ZnO@polymer have been explored in isolation by Pan et al. for in vivo imaging of mice [17]. ZnO@SiO 2 NPs show cytotoxicity as studied This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Synthesis of mesoporous SiO2–ZnO nanocapsules: encapsulation of small biomolecules for drugs and “SiOZO-plex” for gene delivery

Cited by 24 publications

References 63 publications

Investigation of optical, film formation, and magnetic properties of PS latex/SP‐MNPs composites

Investigation of optical, film formation, and magnetic properties of PS latex/SP‐MNPs composites

Recent Advances in Inorganic Nanomaterials Synthesis Using Sonochemistry: A Comprehensive Review on Iron Oxide, Gold and Iron Oxide Coated Gold Nanoparticles

Facile synthesis of multifunctional m‐SiO ₂ @ZnO nanocomposite employing biocompatible polymers for potential theranostic applications

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Synthesis of mesoporous SiO2–ZnO nanocapsules: encapsulation of small biomolecules for drugs and “SiOZO-plex” for gene delivery

Cited by 24 publications

References 63 publications

Investigation of optical, film formation, and magnetic properties of PS latex/SP‐MNPs composites

Investigation of optical, film formation, and magnetic properties of PS latex/SP‐MNPs composites

Recent Advances in Inorganic Nanomaterials Synthesis Using Sonochemistry: A Comprehensive Review on Iron Oxide, Gold and Iron Oxide Coated Gold Nanoparticles

Facile synthesis of multifunctional m‐SiO 2 @ZnO nanocomposite employing biocompatible polymers for potential theranostic applications

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Facile synthesis of multifunctional m‐SiO ₂ @ZnO nanocomposite employing biocompatible polymers for potential theranostic applications