Synthesis of Mesoporous Silica Sba-15 Through Surfactant Set-Up and Hydrothermal Process

Thahir, Ridhawati; Wahab, Abdul Wahid; Nafie, Nursiah La; Raya, Indah

doi:10.31788/rjc.2019.1235306

Cited by 20 publications

(10 citation statements)

References 35 publications

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“…SBA-15 was synthesized according to the improved procedure by Liang Chao et.al [4,5,9]. The previous study has assessed the properties of SBA-15 without co-surfactant PVA in the preparation process of Pluronic surfactant template [21]. A case study approach was near modified to synthesize SBA-15.…”

Section: Synthesis Mesoporous Silica Sba-15mentioning

confidence: 99%

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Synthesis of high surface area mesoporous silica SBA-15 by adjusting hydrothermal treatment time and the amount of polyvinyl alcohol

Thahir¹,

Wahab

Nafie

et al. 2019

Open Chemistry

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The high surface area of mesoporous silica SBA-15 has been synthesized successfully by hydrothermal treatment with direct addition of PVA, triblock copolymer (P123) as a direct structure agent and tetraethyl orthosilicate (TEOS) as a precursor. The mesoporous silica SBA-15 have been characterized with nitrogen physisorption, scanning electron microscopy, Fourier transformed infrared spectroscopy, and x-ray diffraction. Measurement of nitrogen sorption indicated that with the addition of PVA, the surface area is increased but the pore volume and pore diameter is not significantly. The short time of hydrothermal treatment (20 h) and using x-ray diffraction, showed that the morphological structure of silica SBA-15 can be changed to a orthorhombic crystal system. The result of the FTIR and SEM-EDX characteristic indicated the functional groups and morphology of the SBA-15 with a narrow pore size distribution. The BET method has exhibited the largest surface area 1726 m2/g, pore volume 1.4 cm3/g, and pore diameter 3.2 nm. It can be suggested that the silica mesoporous SBA-15 will have potential application prospect in catalysis, storage, and adsorbent.

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Section: Synthesis Mesoporous Silica Sba-15mentioning

confidence: 99%

“…Surface area is a key property of mesoporous materials by physisorption methods [21]. The result obtained from the preliminary analysis of high surface area for SBA-15 is presented in Figure 1.…”

Section: Physisorption Isotherm Analysismentioning

confidence: 99%

Synthesis of high surface area mesoporous silica SBA-15 by adjusting hydrothermal treatment time and the amount of polyvinyl alcohol

Thahir¹,

Wahab

Nafie

et al. 2019

Open Chemistry

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“…The presence of this peak proves the amorphous state of the carrier. In the analyzed temperature range, the SBA-15-A 0.20 is thermally stable as there are no melting or degradation peaks [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Modification of the Release of Poorly Soluble Sulindac with the APTES-Modified SBA-15 Mesoporous Silica

et al. 2021

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The effectiveness of oral drug administration is related to the solubility of a drug in the gastrointestinal tract and its ability to penetrate the biological membranes. As most new drugs are poorly soluble in water, there is a need to develop novel drug carriers that improve the dissolution rate and increase bioavailability. The aim of this study was to analyze the modification of sulindac release profiles in various pH levels with two APTES ((3-aminopropyl)triethoxysilane)-modified SBA-15 (Santa Barbara Amorphous-15) silicas differing in 3-aminopropyl group content. Furthermore, we investigated the cytotoxicity of the analyzed molecules. The materials were characterized by differential scanning calorimetry, powder X-ray diffraction, scanning and transmission electron microscopy, proton nuclear magnetic resonance and Fourier transformed infrared spectroscopy. Sulindac loaded on the SBA-15 was released in the hydrochloric acidic medium (pH 1.2) and phosphate buffers (pH 5.8, 6.8, and 7.4). The cytotoxicity studies were performed on Caco-2 cell line. The APTES-modified SBA-15 with a lower adsorption capacity towards sulindac released the drug in a less favorable manner. However, both analyzed materials improved the dissolution rate in acidic pH, as compared to crystalline sulindac. Moreover, the SBA-15, both before and after drug adsorption, exhibited insignificant cytotoxicity towards Caco-2 cells. The presented study evidenced that SBA-15 could serve as a non-toxic drug delivery system that enhances the dissolution rate of sulindac and improves its bioavailability.

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“…The IR spectrum of Buni fruit extracted with ethanol solvent was measured by Prestige-21 Shimadzu Infrared spectroscopy at the range of 400-4000 cm 3 using KBr pellet 16 to identify its various functional group.…”

Section: Ir Spectroscopy Analysismentioning

confidence: 99%

Total Phenolic Content and Antioxidant Activities of Buni Fruit (Antidesma Bunius L.) in Moncongloe Maros District Extracted Using Ultrasound-Assisted Extraction

Yasser¹,

Rafi²,

Wahyuni³

et al. 2020

RJC

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This study aims to extract Buni Fruit obtained from Moncongloe, Maros district, South Sulawesi, Indonesia, using Ultrasound-Assisted Extraction technology with ethanol as solvent. The effect of extraction temperature on the Total Phenolic Content and Antioxidant Activities of the extract was also studied. The result shows that at the temperature of 50 o C was obtained the best extract with the Total Phenolic Content of 6.7415 ± 0.0721 mg/g in GAE and the value of IC 50 of 29.9618 ± 1.9521 mg/L. This result shows that Buni fruit extract has the potential to be developed as a healthy food.

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Synthesis of Mesoporous Silica Sba-15 Through Surfactant Set-Up and Hydrothermal Process

Cited by 20 publications

References 35 publications

Synthesis of high surface area mesoporous silica SBA-15 by adjusting hydrothermal treatment time and the amount of polyvinyl alcohol

Synthesis of high surface area mesoporous silica SBA-15 by adjusting hydrothermal treatment time and the amount of polyvinyl alcohol

Modification of the Release of Poorly Soluble Sulindac with the APTES-Modified SBA-15 Mesoporous Silica

Total Phenolic Content and Antioxidant Activities of Buni Fruit (Antidesma Bunius L.) in Moncongloe Maros District Extracted Using Ultrasound-Assisted Extraction

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