Synthesis of Manganese Oxide Embedded Carbon Nanofibers as Effective Biomimetic Enzymes for Sensitive Detection of Superoxide Anions Released from Living Cells

Abstract

Carbon nanofiber/manganese oxide (CNF‐MnO) hybrid nanofibers are synthesized by calcination of potassium permanganate (KMnO4) loaded bacterial cellulose (BC) hydrogels. The chemical structure, morphology, performance, and application of CNF‐MnO aerogels are characterized and studied. The results revealed that MnO nanoparticles are uniformly deposited on the surface of CNF which derived from BC hydrogels. An amperometric superoxide anions (O2•−) sensor is fabricated by the immobilization of the CNF‐MnO aerogels on a glassy carbon electrode, which displays a linear amperometric response with a high sensitivity of 76.2 µA cm−2 × 10−3m−1 and a low detection limit of 1.2 × 10−9m in the concentration range of 5.0 × 10−9m – 2.5 × 10−6m. The successful detection of O2•− released from cancer cells verifies the potential application in biomedical field.

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

“…All results proved that PEDOT/MnO 2 nanoellipsoids can achieve catecholamine molecules sensing by the electrochemical method. Using electrochemical biosensors, many other substances can also be detected, such as H 2 O 2 , [44e,120] carcinoembryonic antigen, [121] dopamine, [47c] aflatoxin B 1 , [118b] superoxide anions, [122] etc.…”