Synthesis of magnetic nanoparticles and their dispersions with special reference to applications in biomedicine and biotechnology

Mehta, R. V.

doi:10.1016/j.msec.2017.05.135

Cited by 93 publications

(50 citation statements)

References 141 publications

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“…For example, the process of binding different molecules at MNPs' surfaces could be easily explained by the presence of hydroxyl groups of nanoparticles obtained by co-precipitation [34] which can be negatively or positively charged depending on the pH of the media. Although, non-peptizable particles can be synthesized at pH 7.5 when OH-ligands are free of charge, ligands still remain attached to the MNPs when the pH is kept in the range 6-10.…”

Section: Functionalization and Stabilization Of Magnetic Nanoparticlesmentioning

confidence: 99%

“…Furthermore, a summary of types, shapes and functionalities that have been explored for MNPs in order to be used as carriers for drug delivery in cancer therapy, together with illustrations of biophysicochemical properties, is presented in Figure 2b. For example, the process of binding different molecules at MNPs' surfaces could be easily explained by the presence of hydroxyl groups of nanoparticles obtained by co-precipitation [34] which can be negatively or positively charged depending on the pH of the media. Although, non-peptizable particles can be synthesized at pH 7.5 when OH-ligands are free of charge, ligands still remain attached to the MNPs when the pH is kept in the range 6-10.…”

Section: Functionalization and Stabilization Of Magnetic Nanoparticlesmentioning

confidence: 99%

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Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019

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During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

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Section: Functionalization and Stabilization Of Magnetic Nanoparticlesmentioning

confidence: 99%

Section: Functionalization and Stabilization Of Magnetic Nanoparticlesmentioning

confidence: 99%

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019

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“…Magnetic particles are commercially available with a wide variety of different chemical functionalities [23]. When it comes to nanometer scale, excellent properties are observed, such as high surface-area-to-volume ratio, biocompatibility, good mechanical strength, and superparamagnetism [24]. Depending on the synthetic method used, the size, shape, stability, and dispersity of magnetic nanoparticles (MNPs) can be controlled.…”

Section: Enzyme Immobilization On Magnetic Particlesmentioning

confidence: 99%

Magnetic Microreactors with Immobilized Enzymes—From Assemblage to Contemporary Applications

2018

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Microfluidics, as the technology for continuous flow processing in microscale, is being increasingly elaborated on in enzyme biotechnology and biocatalysis. Enzymatic microreactors are a precious tool for the investigation of catalytic properties and optimization of reaction parameters in a thriving and high-yielding way. The utilization of magnetic forces in the overall microfluidic system has reinforced enzymatic processes, paving the way for novel applications in a variety of research fields. In this review, we hold a discussion on how different magnetic particles combined with the appropriate biocatalyst under the proper system configuration may constitute a powerful microsystem and provide a highly explorable scope.

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“…Magnetic core–shell structures of silica are of great interest to researchers from a wide range of disciplines, including catalysis, biotechnology/biomedicine, magnetic resonance imaging, data storage, and environmental remediation . In recent years, MNPs (e.g., Fe 3 O 4 ) have been extensively investigated as an inorganic catalyst support in the synthesis of organic–inorganic hybrid catalysts because of their good stability, easy synthesis and functionalization, and high surface area, as well as low toxicity and price …”

Section: Introductionmentioning

confidence: 99%

Fe₃O₄@SiO₂@sulfated boric acid as superparamagnetic and recyclable nanocatalyst‐assisted, one‐pot,pseudofour‐component synthesis of 5‐amino‐2‐aryl‐3H‐chromeno[4,3,2‐de][1,6]naphthyridine‐4‐carbonitrile derivatives

Khosravi

Mohammadi

Shaterian

2019

J Chinese Chemical Soc

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The catalytic performance of the superparamagnetic nanocatalyst Fe3O4@SiO2@Sulfated boric acid as a green, recyclable, and acidic solid catalyst in the synthesis of chromeno[4,3,2‐de][1,6]naphthyridine derivatives has been studied. Chromeno[4,3,2‐de][1,6]naphthyridine derivatives via a pseudo four‐component reaction from aromatic aldehydes (1 mmol), malononitrile (2 mmol), and 2′‐hydroxyacetophenone in the presence of Fe3O4@SiO2@Sulfated boric acid (0.004 g) as a nanocatalyst in 3 mL of water as a green solvent at 80°C has been synthesized. The advantages of this method are higher product yields in shorter reaction times, easy recyclability and reusability of the catalyst, and easy work‐up procedures. The nanocatalyst was reused at least six times. The nanocatalyst retained its stability in the reaction, and after reusability, it was separated easily from the reaction by an external magnet.

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Synthesis of magnetic nanoparticles and their dispersions with special reference to applications in biomedicine and biotechnology

Cited by 93 publications

References 141 publications

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

Magnetic Microreactors with Immobilized Enzymes—From Assemblage to Contemporary Applications

Fe₃O₄@SiO₂@sulfated boric acid as superparamagnetic and recyclable nanocatalyst‐assisted, one‐pot,pseudofour‐component synthesis of 5‐amino‐2‐aryl‐3H‐chromeno[4,3,2‐de][1,6]naphthyridine‐4‐carbonitrile derivatives

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Synthesis of magnetic nanoparticles and their dispersions with special reference to applications in biomedicine and biotechnology

Cited by 93 publications

References 141 publications

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

Magnetic Microreactors with Immobilized Enzymes—From Assemblage to Contemporary Applications

Fe3O4@SiO2@sulfated boric acid as superparamagnetic and recyclable nanocatalyst‐assisted, one‐pot,pseudofour‐component synthesis of 5‐amino‐2‐aryl‐3H‐chromeno[4,3,2‐de][1,6]naphthyridine‐4‐carbonitrile derivatives

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About

Fe₃O₄@SiO₂@sulfated boric acid as superparamagnetic and recyclable nanocatalyst‐assisted, one‐pot,pseudofour‐component synthesis of 5‐amino‐2‐aryl‐3H‐chromeno[4,3,2‐de][1,6]naphthyridine‐4‐carbonitrile derivatives