Synthesis of magnetic molecular imprinted polymer with a new functional monomer for dispersive micro solid phase extraction of captopril from wastewater and biological samples and determination by UV-Vis spectrophotometry

Dispersive micro solid phase extraction of glibenclamide from plasma, urine, and wastewater using a magnetic molecularly imprinted polymer followed by its determination by a high-performance liquid chromatography-photodiode array detector

“…The imprinting factor (IF) describes the tendency of the MMIP for selective identification and sorption affinity of recognition sites toward the imprinted GLB molecule. It is calculated by the following equation: 22 where Q MMIP and Q MNIP are the binding capacities of the synthesized MMIP and MNIP toward GLB, respectively. The IF was calculated to be 5.9, which validates the imprint of strongly selective binding sites for GLB in the synthesized MMIPs.…”

“…Magnetic iron nanoparticles (Fe 3 O 4 ), SiO 2 @Fe 3 O 4 nanoparticles, SiO 2 -MPS@Fe 3 O 4 , MMIP, and MNIP were fabricated using the precipitation polymerization method according to previous works with some modification. 22,23 The schematic of MMIP synthesis is shown in Fig. 1 .…”

“…Twenty microliters of it were then injected into the HPLC-PDA system. The extraction efficiency was calculated by the following equation: 22 where C i and C e are the initial and equilibrium concentrations of GLB in μg L −1 , respectively.…”

“… 21 Furthermore, magnetic sorbents can be easily reused and recycled, making them both cost-effective and eco-friendly. 22,23 Until now, different non-magnetic or magnetic sorbents, such as S@SnO 2 -NPs, 13 Fe 3 O 4 @PPy NPs, 24 CoFe 2 O 4 /MCM-48/chitosan, 25 and SiO 2 -coated Fe 3 O 4 , 26 have been utilized for SPE of glibenclamide from various media.…”

“… 27 Surface imprinted polymers have recognition sites on the support surface that allow them to enjoy the benefits of the ease of accessibility of the cavity by the template molecule, fast mass transfer, ease of elution of the extracted analyte, high binding capacity, and kinetics. 28 Different supports, including magnetic nanoparticles, 22 polymeric supports, 29 titanium dioxide particles, 30 carbon nanotubes, 31 and silica particles, 32 have been used for the synthesis of surface MIPs. Among these supports, the MIPs synthesized on magnetic materials (such as Fe 3 O 4 ) have the aforementioned advantages typical of the MIPs, as well as the possibility of dispersion of the sorbent in solution, followed by its facile separation with a potent magnetic field.…”