Synthesis of luteolin loaded zein nanoparticles for targeted cancer therapy improving bioavailability and efficacy

Shinde, Priyanka; Agraval, Hina; Singh, Ajeet; Yadav, Umesh C.S.; Kumar, Umesh

doi:10.1016/j.jddst.2019.04.044

Cited by 56 publications

(29 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It helps to reduce the epidermal growth factor-induced markers as well as restoration of cell-cell junctions [1,7]. LT-loaded nanoformulations such as folacin-modified nanoparticle [8], nanoparticles [9,10], NLCs [11], folic acid-modified ROS-responsive nanoparticles [12], and nanospheres [13] have been prepared and enhanced bioavailability and efficacy have been reported. However, the application of LT vesicles in the skin cancer has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and Evaluation of Luteolin-Loaded Topical Nanoparticulate Delivery System for the Skin Cancer

et al. 2021

View full text Add to dashboard Cite

In the present study, luteolin (LT)-loaded nanosized vesicles (LT-NVs) were prepared by a solvent evaporation–hydration method using phospholipid and edge activator. The formulation was optimized using three factors at a three-level Box–Behnken design. The formulated LT-NVs were prepared using the three independent variables phospholipid (A), edge activator (B) and sonication time (C). The effect of used variables was assessed on the vesicle size (Y1) and encapsulation efficiency (Y2). The selection of optimum composition (LT-NVopt) was based on the point prediction method of the software. The prepared LT-NVopt showed the particle size of 189.92 ± 3.25 nm with an encapsulation efficiency of 92.43 ± 4.12% with PDI and zeta potential value of 0.32 and −21 mV, respectively. The formulation LT-NVopt was further converted into Carbopol 934 gel (1% w/v) to enhance skin retention. LT-NVoptG was further characterized for viscosity, spreadability, drug content, drug release, drug permeation and antioxidant, antimicrobial and cytotoxicity assessment. The evaluation result revealed optimum pH, viscosity, spreadability and good drug content. There was enhanced LT release (60.81 ± 2.87%), as well as LT permeation (128.21 ± 3.56 µg/cm2/h), which was found in comparison to the pure LT. The antioxidant and antimicrobial study results revealed significantly (p ˂ 0.05) better antioxidant potential and antimicrobial activity against the tested organisms. Finally, the samples were evaluated for cytotoxicity assessment using skin cancer cell line and results revealed a significant difference in the viability % at the tested concentration. LT-NVoptG showed a significantly lower IC50 value than the pure LT. From the study, it can be concluded that the prepared LT-NVoptG was found to be an alternative to the synthetic drug as well as conventional delivery systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and Evaluation of Luteolin-Loaded Topical Nanoparticulate Delivery System for the Skin Cancer

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Nanostructured lipid carriers and microemulsions of luteolin improved the oral bioavailability in rats 24 . Luteolin loaded zein nanoparticles showed enhanced cytotoxicity against SW480 colon cancer cells and induce apoptosis by enhancing its bioavailability 25 . The plasma levels of the luteolin reached the highest peak with 1.1 h after oral administration of Chrysanthemum morifolium extract to rats 26 .…”

Section: Oral Absorption and Bioavailability Of Luteolinmentioning

confidence: 99%

Role of luteolin in overcoming Parkinson's disease

Siddique

2021

BioFactors

View full text Add to dashboard Cite

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting elderly people (>60 years old) worldwide. There is no permanent cure for the disease but the symptomatic relief can be obtained by using dopamine agonists besides L-dopa therapy. The longer use of the drugs is associated with several side effects. Hence, the researchers have made a considerable attention toward the development of neuroprotective agents from plants. A number of phytochemicals have been demonstrated for their protective effects in various in vitro, in vivo, and clinical studies. In this context, luteolin, a flavone which is present in fruits and vegetables has been attributed to a number of pharmacological properties including neuroprotective. The present review demonstrates the bioavailability, oral absorption, and mechanism of action against PD.

show abstract

“…The biopolymer drug carriers (zein, chitosan, etc.) make it more bioavailable [ 154 – 156 ]. The elongated antioxidant activity of luteolin encapsulated with starch nanoparticles is proved.…”

Section: Classification Of Flavonoidsmentioning

confidence: 99%

Natural Biocidal Compounds of Plant Origin as Biodegradable Materials Modifiers

Pawłowska

Stepczyńska

2021

J Polym Environ

View full text Add to dashboard Cite

The article presents a literature review of the plant origin natural compounds with biocidal properties. These compounds could be used as modifiers of biodegradable materials. Modification of polymer material is one of the basic steps in its manufacturing process. Biodegradable materials play a key role in the current development of materials engineering. Natural modifiers are non-toxic, environmentally friendly, and renewable. The substances contained in natural modifiers exhibit biocidal properties against bacteria and/or fungi. The article discusses polyphenols, selected phenols, naphthoquinones, triterpenoids, and phytoncides that are natural antibiotics. Due to the increasing demand for biodegradable materials and the protection of the natural environment against the negative effects of toxic substances, it is crucial to replace synthetic modifiers with plant ones. This work mentions industries where materials containing natural modifying additives could find potential applications. Moreover, the probable examples of the final products are presented. Additionally, the article points out the current world’s pandemic state and the use of materials with biocidal properties considering the epidemiological conditions.

show abstract

Synthesis of luteolin loaded zein nanoparticles for targeted cancer therapy improving bioavailability and efficacy

Cited by 56 publications

References 40 publications

Formulation, Optimization and Evaluation of Luteolin-Loaded Topical Nanoparticulate Delivery System for the Skin Cancer

Formulation, Optimization and Evaluation of Luteolin-Loaded Topical Nanoparticulate Delivery System for the Skin Cancer

Role of luteolin in overcoming Parkinson's disease

Natural Biocidal Compounds of Plant Origin as Biodegradable Materials Modifiers

Contact Info

Product

Resources

About