Synthesis of less toxic gold nanorods by using dodecylethyldimethylammonium bromide as an alternative growth-directing surfactant

Allen, Jessica; Xu, Junpeng; Blahove, Maria Raisa; Canonico-May, Stephanie; Santaloci, Taylor J.; Braselton, Martha E.; Stone, John W.

doi:10.1016/j.jcis.2017.06.101

Cited by 31 publications

(35 citation statements)

References 20 publications

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“…Many researchers improved the characters of the final products by adjusting the parameters during the synthetic process. For instance, repeated cleaning and changing a less toxic surfactant such as C12EDMAB (Allen et al, 2017) could effectively reduce the cytotoxicity. The ARs, sizes, shapes, monodispersity, and yield of GNRs vary when the synthetic environment is changed, including temperature, pH, time, and concentration.…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

“…The process can be divided into three steps: 1) citrate-capped gold nanospheres used as seeds are formed after the reduction of HAuCl 4 by NaBH 4 , 2) the growth solution that contained HAuCl 4 and cetyltrimethylammonium bromide (CTAB) is prepared, and 3) GNRs are acquired by adding seeds to the growth solution and ascorbic acid (AA; Jana et al, 2001;Xia et al, 2015). However, the low yield and unsatisfied size of GNRs synthesized in this original way make it inappropriate for applications (Scarabelli et al, 2015;Allen et al, 2017), so there appears an endless stream of improvements in accordance with the requirements based on GNRs applications in PTT. GNRs suitable for PTT require good monodispersity, small size (An et al, 2017;Cheng et al, 2019), anisotropy, no toxicity, and the need to be produced in high yields.…”

Section: Seedless Methodsmentioning

confidence: 99%

“…Besides removing CTAB as much as possible to reduce its concentration, switching to other nontoxic surfactants is also an excellent way to reduce the toxicity of GNRs. Xu, Blahove et al led the synthesis of GNRs with less toxicity using a less toxic surfactant, dodecyl dimethyl ammonium bromide (C12edmab), as an alternative (Allen et al, 2017). Hollow GNRs with controllable AR were synthesized by Cai et al with nontoxic modifiers, which also reduced toxicity (Cai et al, 2018).…”

Section: Reduce Toxicitymentioning

confidence: 99%

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Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

et al. 2021

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Cancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it into heat, thus killing tumor cells. Gold nanorods (GNRs) have attracted widespread attention in recent years due to their unique optical and electronic properties and potential applications in biological imaging, molecular detection, and drug delivery, especially in the PTT of cancer and other diseases. This review summarizes the recent progress in the synthesis methods and surface functionalization of GNRs for PTT. The current major synthetic methods of GNRs and recently improved measures to reduce toxicity, increase yield, and control particle size and shape are first introduced, followed by various surface functionalization approaches to construct a controlled drug release system, increase cell uptake, and improve pharmacokinetics and tumor-targeting effect, thus enhancing the photothermal effect of killing the tumor. Finally, a brief outlook for the future development of GNRs modification and functionalization in PTT is proposed.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

Section: Seedless Methodsmentioning

confidence: 99%

Section: Reduce Toxicitymentioning

confidence: 99%

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Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

et al. 2021

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“…The change of CTAB as a soft-template agent with the less toxic dodecylethyldimethylammonium bromide (C 12 EDMAB) has been explored by Stone’s group [ 31 ]. The authors developed a modified seed-mediated protocol introducing, successfully, the new templating agent and showing that even the amount of C 12 EDMAB needed was higher than CTAB, the toxicity induced on Hep-2 and A549 cells was lower.…”

Section: Synthesismentioning

confidence: 99%

Anisotropic Gold Nanoparticles in Biomedical Applications

Kohout

Santi

Polito

2018

IJMS

105

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Gold nanoparticles (AuNPs) play a crucial role in the development of nanomedicine, principally due to their unique photophysical properties and high biocompatibility. The possibility to tune and customize the localized surface plasmon resonance (LSPR) toward near-infrared region by modulating the AuNP shape is one of the reasons for the huge widespread use of AuNPs. The controlled synthesis of no-symmetrical nanoparticles, named anisotropic, is an exciting goal achieved by the scientific community which explains the exponential increase of the number of publications related to the synthesis and use of such type of AuNPs. Even with such steps forward and the AuNP translation in clinic being done, some key issues are still remain and they are related to a reliable and scalable production, a full characterization, and to the development of nanotoxicology studies on the long run. In this review we highlight the very recent advances on the synthesis of the main classes of anisotropic AuNPs (nanorods, nanourchins and nanocages) and their use in the biomedical fields, in terms of diagnosis and therapeutics.

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“…Even though the majority of researches concerned its applications in the medical field, nanogold has a wide variety of applications such as catalysis (Huang et al 2012;Mallat and Baiker 2004;Obradović and Gojković 2013;Panjan et al 2012), drug delivery systems (Huang et al 2006;Norman et al 2008;Stone et al 2011), sensors (Pérez et al 2015;Wu and Tseng 2011), and cancer diagnosis and therapy (Pérez et al 2015;Arachchige et al 2015;Suneetha et al 2014). This wide range of applications of nanogold is devoted to its unique Optical as well as Thermal properties, controllable aspect ratio, and low toxicity (Allen et al 2017). There are many studied techniques for the preparation of nanogold.…”

Section: Introductionmentioning

confidence: 99%

Influence of different stabilizers on the morphology of gold nanoparticles

et al. 2019

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Objectives: The current study revealed that the used stabilizers greatly affect the morphology as well as the aspect ratio of the obtained gold nanoparticles.Background: Control of the morphology and dimensions of gold nanoparticles during the preparation is an important task for targeting certain applications in demand. Material and methods: Gold nanoparticles were prepared by the reduction of tetrachloroauric(III) acid in the presence of different stabilizers: polyethyleneimine (PEI), polyvinylpyrrolidone (PVP), and chitosan. Results: In the case of using polyethyleneimine, the produced nanoparticles showed a homogenous spherical structure. Meanwhile, in the case of using polyvinylpyrrolidone and chitosan, the produced nanoparticles experience non-homogenous morphology with great diversity. Transmission electron microscopy (TEM) and UVvisible spectrophotometry (UV-vis) techniques were employed to study the criteria of the obtained gold nanoparticles.Conclusions: It was obviously concluded that the type and concentration of the reducing agents that were added during gold preparation and acted as stabilizer templates affect to a great extent the morphology and particle shape. Also, stabilizers affect the homogeneity of the produced gold nanoparticles. In the case of using polyethyleneimine, the produced nanoparticles showed a homogenous spherical structure. Meanwhile, in the case of polyvinylpyrrolidone and chitosan, the produced nanoparticles experience non-homogenous morphology with great diversity.

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Synthesis of less toxic gold nanorods by using dodecylethyldimethylammonium bromide as an alternative growth-directing surfactant

Cited by 31 publications

References 20 publications

Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

Anisotropic Gold Nanoparticles in Biomedical Applications

Influence of different stabilizers on the morphology of gold nanoparticles

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