Synthesis of ?-lactones by the hydroborylation and oxidation of homoallylig alcohols

An iterative approach to higher polyquinanes

“…The first step involves the reaction of the carbonyl compound 5 with allyl magnesium bromide 7 followed by the hydroboration-oxidation sequence. The key step in this strategy is the generation of spiro-lactone 7 without the involvement of protective groups as compared to the literature methods.…”