Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Zhang, Chen; Bu, Wenbo; Ni, Dalong; Zhang, Shenjian; Li, Qing; Yao, Zhenwei; Zhang, Jiawen; Yao, Heliang; Wang, Zheng; Shi, Jianlin

doi:10.1002/anie.201510031

Cited by 1,012 publications

(676 citation statements)

References 35 publications

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“…Recently, a number of approaches based on this assumption have been described, such as Fenton reaction. 205,313 …”

Section: Non-photodynamic Approachesmentioning

confidence: 99%

“…19A ). 313 The AFe-NPs showed remarkable advantages over the corresponding crystalline iron nanocrystals (FeNCs) in cancer therapy benefiting from their amorphous nature. This chemodynamic therapy (CDT) paradigm that combines the specific property of cargo and tumour microenvironment promises efficient on-demand generation of HO• from H 2 O 2 ( Fig.…”

Section: Non-photodynamic Approachesmentioning

confidence: 99%

“…205 In this regard, CDT can be an alternative tool for ROS generation internalized by endogenous chemical energy without the need for external input of laser irradiation or local oxygen, thus circumventing the limitations posed by the penetration depth of light through tissues and the hypoxic tumour environment. 205, 313 …”

Section: Non-photodynamic Approachesmentioning

confidence: 99%

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Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.

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“…Recently, a number of approaches based on this assumption have been described, such as Fenton reaction. 205,313 …”

Section: Non-photodynamic Approachesmentioning

confidence: 99%

Section: Non-photodynamic Approachesmentioning

confidence: 99%

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Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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“…They reported on a design and facile synthesis of AFeNPs as shown in Figure 8A. [51] The in vitro studies demonstrated that the AFeNPs can be used for cancer therapy in the presence of H 2 O 2 at pH 6.5 (Figure 8B, C). The tumor growth can be inhibited by the AFeNPs that can induce a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H 2 O 2 in the tumor microenvironment (Figure 8D, E).…”

Section: Nanomaterials For Ferroptosis-based Cancer Therapymentioning

confidence: 99%

Emerging Strategies of Cancer Therapy Based on Ferroptosis

et al. 2018

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Ferroptosis, a new form of regulated cell death that is iron- and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental compounds, and genes. A plethora of research work has outlined the blueprint of ferroptosis as a new option for cancer therapy. However, the published ferroptosis-related reviews have mainly focused on the mechanisms and pathways of ferroptosis, which motivated this contribution to bridge the gap between biological significance and material design. Therefore, it is timely to summarize the previous efforts on the emerging strategies for inducing ferroptosis and shed light on future directions for using such a tool to fight against cancer. Here, the current strategies of cancer therapy based on ferroptosis will be elaborated, the design considerations and the advantages and limitations are highlighted, and finally a future perspective on this emerging field is given.

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“…[95] Moreover, by using iron nanometallic materials, it will enable the disproportionation of hydrogen peroxide, which is usually over-produced within the tumor area, to efficiently generate hydroxyl radicals in the Fenton reaction, chemodynamic therapy (CDT) can thus be achieved by using endogenous chemical energy to produce reactive oxygen species, which can vanish the existence of tumor within 4T1 xenograft bearing mice. [96] …”

Section: Alternative Nanomedicinesmentioning

confidence: 99%

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Balasubramanian

Liu

Hirvonen

et al. 2017

Adv Healthcare Materials

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Explosive growth of nanomedicines continues to significantly impact the therapeutic strategies for effective cancer treatment. Despite the significant progress in the development of advanced nanomedicines, successful clinical translation remains challenging. As cancer nanomedicine is a multidisciplinary field, the fundamental problem is that the knowledge gaps stem from different vantage points in the understanding of cancer nanomedicines. The complexities and heterogenecity of both nanomedicines and cancer are further demanding the integration of highly diverse expertise to develop clinically translatable cancer nanomedicines. This progress report aims to discuss the current understanding of cancer nanomedicines between different research areas in terms of nanoparticle engineering, formulation, tumor patho-physiology and clinical medicine, as well as to identify the knowledge gaps lying at the interface between the different fields of research in nanomedicine. Here we also highlight for the necessity to harmonize the multidisciplinary effort in the research of nanomedicines in order to bridge the knowledge and to advance the full understanding in cancer nanomedicines. A paradigm shift is needed in the strategic development of disease specific nanomedicines in order to foster the successful translation into clinic of future cancer nanomedicines.

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Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Cited by 1,012 publications

References 35 publications

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Emerging Strategies of Cancer Therapy Based on Ferroptosis

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

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