Synthesis of iodomethyl sulphoxides

Abstract

Iodomethyl sulphoxides may be synthesized in good yields by the reaction of diazomethane with sulphinyl chlorides in the presence of alkali metal iodides.RECENTLY, there has been considerable interest in the chemistry of a-substituted sulph~xides.l-~ We have now discovered that the addition of sulphinyl chlorides to diazo-compounds, a recently reported preparation of a-chloro-sulphoxides, may be adapted to the preparation of

Helices at interfaces

“…We may speculate whether abnormal wavy shapes or enhanced closure of confined filaments found in literature are fingerprints of an otherwise hidden helical superstructures whose microscopic origin should be elucidated for each type of filament, case by case. Such peculiar behavior under confinement is observed for essential filaments like microtubules [7], F-actin [28] and possibly for intermediate filaments [31]. It has not escaped our attention that actin filaments circularize on stunningly small scales (∼5µm length rings) [28], [29] and exhibit wavy periodic tangent-correlation functions in narrow, flat -channels (cf.…”

“…The list of examples is close to innumerable with the most prominent ones: FtsZ [1], Mrb [2], bacterial flagella [3,4], tropomyosin [5] and intermediate filaments [6]. More recently microtubules were suggested to spontaneously form large scale superhelices [7,8]. Even whole microorganisms exhibit helicity inherited from their constituent filaments [9].…”