“…Initial efforts have been recently reported for the development of models that simultaneously integrate mass and energy (Savalescu et al, 2005a(Savalescu et al, , 2005bLiao et al, 2011;Martinez-Patiño et al, 2011Tan et al, 2012;Zhou et al, 2012aZhou et al, , 2012bBiox et al, 2012;Rojas-Torres et al, 2013;Ibric et al, 2013;Liu et al, 2013;Kravanja, 2013, 2014). In such works, the contribution of mass integration is typically based on the concentration of contaminants, thus ignoring the role that streams properties play in the design of the network.…”