“…Although the Boc‐based ones have proven to be successful26, the Fmoc‐based ones have offered varying levels of success26–29. In general, the Fmoc‐based syntheses use polystyrene resins, such as the Wang resin, and differ in their approach in resolving undesired self‐association of the growing sequence, encompassing the use of Hmb‐amide protecting groups26, 27 Dmb‐protected dipeptides29, a mixture of DMF/NMP as solvent30, and/or high temperatures28, 31. However, using extreme conditions for amino acid couplings—especially high temperatures—can decrease the quality of the desired peptide, chiefly due to side reactions such as amino acid racemisation1.…”