Synthesis of indole–quinoline–oxadiazoles: their anticancer potential and computational tubulin binding studies

Synthesis and Insecticidal Activity of New Quinoline Derivatives Containing Perfluoropropanyl Moiety

“…For instance, the famous anti‐malaria drug quinine is exacted from the congeneric plants firstly. Neither natural quinoline derivatives nor synthetic quinoline derivatives always displayed diversity activities, such as antioxidant activity , antitubercular agents , trypanocidal activities , anticancer , antibacterial activity , aromatase inhibitors , and multi‐trypanosomatid activity . So the synthesis of novel quinoline derivatives has been attracted by many organic chemists.…”

Synthesis and in vivo fungicidal activity of some new quinoline derivatives against rice blast

“…In modern synthetic chemistry, quinoline compounds have been applied in many fields, such as coordination chemistry, organometallic chemistry, asymmetric synthesis, medicinal chemistry, pesticide chemistry, and materials chemistry. Quinoline is one of the most common chemical skeletons of synthesis chemistry and has been used to discover a number of important bioactive compounds, such as anti‐tubercular agents, anti‐cancer drugs, antioxidants, aromatase inhibitors, multi‐trypanosomatids, trypanocidals, antibacterial agents, etc. Therefore, the synthesis of new quinolone derivatives has attracted many organic chemists.…”

Novel quinoline derivatives carrying nitrones/oximes nitric oxide donors: Design, synthesis, antiproliferative and caspase-3 activation activities

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Novel quinoline derivatives carrying nitrones and oxime as nitric oxide donors were prepared and characterized using different spectroscopic techniques. Several mechanisms can explain the anticancer effect of quinoline derivatives including: topoisomerase inhibition, [21][22][23] DNA intercalation, [24] protein kinases inhibition, [25][26][27] tubulin polymerase inhibition, [28][29][30][31] and induction of apoptosis. Antiproliferative screening results showed that the 2-benzylthioquinoline nitrones 6e and 6f and the 2-methylthio analogues 6g and 6h exhibited promising antiproliferative activity especially against leukemia and colon cancer cell lines.

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