Synthesis of indole derivatives as prevalent moieties present in selected alkaloids

Abstract

In this review, we aim to highlight the synthesis of indoles as a moiety in selected alkaloids.

pH‐Triggered Recovery of Organic Polymer Photocatalytic Particles for the Production of High Value Compounds and Enhanced Recyclability

“…The promising performance of NP‐BT‐PDPAH + in the photocatalytic reductive and oxidative transformations has encouraged us to examine its potential in performing redox reactions. Indole has been widely used as an important building block for the production of biologically active compounds [54, 55] . The N‐1, C‐2 to C‐6, or C‐7 positions of indole can be substituted to produce versatile indole derivatives, demonstrating a diverse scaffold for drug design [56–59] .…”

Progressive study on ruthenium catalysis for de(hydrogenative) alkylation and alkenylation using alcohols as a sustainable source

“…Among the different heterocyclic systems, nitrogen-bearing heterocycle rings are much more abundant in nature as important bioactive compounds. 59 Thus, the functionalization of heterocyclic scaffolds is highly important. Here, the Ru-catalysed alkylation of heteroarenes using alcohols to obtain important functionalized heteroarenes is discussed in detail.…”

Indole Derived Anticancer Agents

“…Due to the slightly acidic nature of the ‐NH bond are capable of N‐substitution reactions under basic conditions. During 1866, Adolph von Bayer synthesized the first indole [17] . Numerous synthetic schemes were published for the indole scaffold as a result of its diverse biological and pharmacological applications [18–23] .…”

“…During 1866, Adolph von Bayer synthesized the first indole. [17] Numerous synthetic schemes were published for the indole scaffold as a result of its diverse biological and pharmacological applications. [18][19][20][21][22][23] The indole derivatives (Figure 1) such as vinblastine, [24] vizimpro, [25] rubraca, [26] rydapt, [27] vinorelbine, [28] sutent, [29] vincristine, [30] alecensa [31] and vinflunine [32] got market approval by Food and drug administration (FDA) to be used as anticancer agents.…”