Synthesis of Indole-2-methylsulfonamides by Domino Sonogashira Coupling and Hydroamination Reaction

Abstract

A domino Sonogashira coupling and hydroamination reaction between o-iodo-N,N-dimethylaniline derivatives and propargyl sulfonamides are described. This protocol allows access to a variety of indole-2-methylsulfonamides in good to excellent yields. The structures of the synthesized compounds are confirmed by XRD studies. Results and DiscussionThe required precursors of our present study, o-iodoaniline derivatives (20a-c) [15] and propargyl sulfonamide derivatives [a] S.