Synthesis of indazole substituted-1,3,4-thiadiazoles and their anticonvulsant activity

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

“…In another series of compounds synthesized by Harish et al, compounds 96a and 96b were reported to be most potent. These compounds exhibited 75.87 and 75.84% protection respectively [173]. Amongst various compounds synthesized by Kumari et al, compound 97 emerged as the most potent and safe anticonvulsant agent [174].…”

Synthesis, Characterisation and In Vitro Biological Evaluation of Novel 3-Chloro-1-(5-ethyl-[1,3,4] thiadiazole-2-yl)-4-phenyl-azetidin-2-one Derivatives

“…The vital interest of the pharmaceutical and agrochemical industries in heterocycles is often connected with their natural occurrence 1 . A survey of the literature revealed that heterocyclic compound differently substituted 1,3,4-thiadiazoles and annulated 1,3,4-thiadiazoles have wide range of pharmacological activities such as antibacterial, antifungal 2 , antituberculosis 3 , antileishmanial 4 , anti-inflammatory 5 , analgesic 6 , antidepressant 7 , antitumor 8 , antioxidant 9 and anticonvulsant activities 10 . The 2-azetidinone ring system, a common structural feature of a number of wide spectrum β-lactam antibiotics, including penicillins, cephalosporins, carbapenems, nocardicins and monobactams, which…”

Directed assembly of cobalt(II) 1-H-indazole-3-carboxylic acid coordination networks by bipyridine and its derivatives: structural versatility, electrochemical properties, and antifungal activity

“…In addition, the outstandingly biological activities of Co complexes 1-3 may result from the formation of H bonds through the non-chelating carboxyl group and the heteroatom of indazole blocks with the active component of cell membrane. The general tendency of growth inhibition against C. musarum was observed in the following reactivity order: [Co(HL − ) 2 …”

“…To date, much effort has been devoted to design and synthesize a new structure of indazole carboxylic acid derivatives through molecular docking and chemical modification [1][2][3][4]. However, only a few researchers focused on the property and application of its coordination complexes.…”

“…Therefore, we intended to synthesize three new cobalt coordination polymers with the combination of H 2 L and bipyridine compounds. The three cobalt-organic frameworks were characterized and described, namely, 3D [Co(HL − ) 2 2 (DPP)] n (3) coordination polymers. Complexes 1-3 were synthesized using the main structural block of 1-H-indazole-3-carboxylic acid (H 2 L) assembled by the flexible ligands of 4,4′-bipyridine (BPY), 1,2-bis(4-pyridyl)ethane (BPE), and 1,3-bis(4-pyridyl)propane (DPP), respectively.…”